Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission.
Cytometry A
; 99(5): 466-471, 2021 05.
Article
in English
| MEDLINE | ID: covidwho-1064342
ABSTRACT
During the second surge of COVID-19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec-1, one of the numerous IFN-stimulated genes) upon admission to intensive care units of 45 patients with RT-PCR-confirmed SARS-CoV2 pulmonary infection. Overall, CD169 expression was strongly induced on circulating monocytes of COVID-19 patients compared with healthy donors and patients with bacterial sepsis. Beyond its contribution at the emergency department, CD169 testing may be also helpful for patients' triage at the ICU to rapidly reinforce suspicion of COVID-19 etiology in patients with acute respiratory failure awaiting for PCR results for definitive diagnosis.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Patient Admission
/
Monocytes
/
Sialic Acid Binding Ig-like Lectin 1
/
SARS-CoV-2
/
COVID-19
/
Intensive Care Units
Type of study:
Cohort study
/
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Cytometry A
Year:
2021
Document Type:
Article
Affiliation country:
Cyto.a.24315
Similar
MEDLINE
...
LILACS
LIS