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Efficacy of convalescent plasma therapy for COVID-19: A systematic review and meta-analysis.
Vegivinti, Charan T R; Pederson, John M; Saravu, Kavitha; Gupta, Nitin; Evanson, Kirk W; Kamrowski, Shelby; Schmidt, Megan; Barrett, Averi; Trent, Hannah; Dibas, Mahmoud; Reierson, Natalie L; Mikoff, Nick; Pisipati, Sailaja; Joseph, Betsy A; Selvan, Pragadeesh T; Dmytriw, Adam A; Pulakurthi, Yashwitha S; Keesari, Praneeth R; Sriram, Varsha; Chittajallu, Spandana; Brinjikji, Waleed; Katamreddy, Rewanth R; Chibbar, Richa; Davis, Amber R; Malpe, Manashree; Mishra, Hemant K; Kallmes, Kevin M; Hassan, Ameer E.
  • Vegivinti CTR; Department of General Medicine, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
  • Pederson JM; Nested Knowledge, St. Paul, Minnesota, USA.
  • Saravu K; Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
  • Gupta N; Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
  • Evanson KW; Superior Medical Experts, St. Paul, Minnesota, USA.
  • Kamrowski S; Nested Knowledge, St. Paul, Minnesota, USA.
  • Schmidt M; Nested Knowledge, St. Paul, Minnesota, USA.
  • Barrett A; Nested Knowledge, St. Paul, Minnesota, USA.
  • Trent H; Nested Knowledge, St. Paul, Minnesota, USA.
  • Dibas M; Sulaiman Al Rajhi University, College of Medicine, Saudi Arabia.
  • Reierson NL; Nested Knowledge, St. Paul, Minnesota, USA.
  • Mikoff N; Nested Knowledge, St. Paul, Minnesota, USA.
  • Pisipati S; Department of Gastroenterology, Mayo Clinic, Scottsdale, Arizona, USA.
  • Joseph BA; Nested Knowledge, St. Paul, Minnesota, USA.
  • Selvan PT; Department of General Medicine, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
  • Dmytriw AA; Neuroradiology & Neurointervention Service, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Pulakurthi YS; Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana, India.
  • Keesari PR; Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana, India.
  • Sriram V; Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
  • Chittajallu S; Rangaraya Medical College, Kakinada, Andhra Pradesh, India.
  • Brinjikji W; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Katamreddy RR; Department of General Surgery, Kempegowda Institute of Medical Sciences, Bangalore, Karnataka, India.
  • Chibbar R; Department of Medicine, Lakeridge Health, Oshawa, Ontario, Canada.
  • Davis AR; Superior Medical Experts, St. Paul, Minnesota, USA.
  • Malpe M; Superior Medical Experts, St. Paul, Minnesota, USA.
  • Mishra HK; University of Minnesota, Twin Cities, Minnesota, USA.
  • Kallmes KM; Nested Knowledge, St. Paul, Minnesota, USA.
  • Hassan AE; Department of Neuroradiology, Valley Baptist Medical Center, Harlingen, Texas, USA.
J Clin Apher ; 36(3): 470-482, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1064370
ABSTRACT
The purpose of this systematic review and meta-analysis was to examine clinical outcomes associated with convalescent plasma therapy in COVID-19 patients. We performed a literature search on PubMed, medRxiv, Web of Science, and Scopus to identify studies published up to December 10th, 2020 that examined the efficacy of convalescent plasma treatment for COVID-19. The primary endpoints were mortality, clinical improvement, and hospital length of stay. We screened 859 studies that met the search criteria, performed full-text reviews of 56 articles, and identified 15 articles that fulfilled inclusion criteria for meta-analysis. The odds of mortality were significantly lower in the convalescent plasma group compared to the control group (OR = 0.59 [95% CI = 0.44; 0.78], P < .001), although results from two key randomized controlled trials did not support the mortality benefit. The odds of clinical improvement were significantly higher in the convalescent plasma group compared to the control group (OR = 2.02 [95% CI = 1.54; 2.65], P < .001). There was no difference in hospital length of stay between the convalescent plasma group and the control group (MD = -0.49 days [95% CI = -3.11; 2.12], P = .713). In all, these data indicate that a mortality benefit with convalescent plasma is unclear, although there remain benefits with convalescent plasma therapy for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: COVID-19 Subject: COVID-19 Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors / Systematic review Language: English Journal: J Clin Apher Clinical aspect: Etiology / Therapy Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: COVID-19 Subject: COVID-19 Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors / Systematic review Language: English Journal: J Clin Apher Clinical aspect: Etiology / Therapy Year: 2021
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