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Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus.
Cocozza, Federico; Névo, Nathalie; Piovesana, Ester; Lahaye, Xavier; Buchrieser, Julian; Schwartz, Olivier; Manel, Nicolas; Tkach, Mercedes; Théry, Clotilde; Martin-Jaular, Lorena.
  • Cocozza F; INSERM U932 Institut Curie Centre de Recherche PSL Research University Paris France.
  • Névo N; Université de Paris Paris France.
  • Piovesana E; INSERM U932 Institut Curie Centre de Recherche PSL Research University Paris France.
  • Lahaye X; INSERM U932 Institut Curie Centre de Recherche PSL Research University Paris France.
  • Buchrieser J; Université de Paris Paris France.
  • Schwartz O; INSERM U932 Institut Curie Centre de Recherche PSL Research University Paris France.
  • Manel N; Virus and Immunity Unit Institut Pasteur and CNRS UMR 3569 Paris France.
  • Tkach M; Virus and Immunity Unit Institut Pasteur and CNRS UMR 3569 Paris France.
  • Théry C; INSERM U932 Institut Curie Centre de Recherche PSL Research University Paris France.
  • Martin-Jaular L; INSERM U932 Institut Curie Centre de Recherche PSL Research University Paris France.
J Extracell Vesicles ; 10(2): e12050, 2020 12.
Article in English | MEDLINE | ID: covidwho-1064378
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ABSTRACT
SARS-CoV-2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by host TMPRSS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing ACE2 and demonstrate that ACE2-EVs are efficient decoys for SARS-CoV-2 S protein-containing lentivirus. Reduction of infectivity positively correlates with the level of ACE2, is much more efficient than with soluble ACE2 and further enhanced by the inclusion of TMPRSS2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Limits: Humans Language: English Journal: J Extracell Vesicles Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Angiotensin-Converting Enzyme 2 / COVID-19 Limits: Humans Language: English Journal: J Extracell Vesicles Year: 2020 Document Type: Article