Your browser doesn't support javascript.
In vitro comparison of unit dose vs infusion pump administration of albuterol via high-flow nasal cannula in toddlers.
Li, Jie; Wei, Wu; Fink, James B.
  • Li J; Division of Respiratory Care, Department of Cardiopulmonary Sciences, Rush University Medical Center, Chicago, Illinois.
  • Wei W; Department of Critical Care Medicine, Shanghai Zhongshan Hospital, Fu Dan University, Shanghai, China.
  • Fink JB; Division of Respiratory Care, Department of Cardiopulmonary Sciences, Rush University Medical Center, Chicago, Illinois.
Pediatr Pulmonol ; 55(2): 322-329, 2020 02.
Article in English | MEDLINE | ID: covidwho-1064412
ABSTRACT

OBJECTIVES:

Transnasal pulmonary aerosol delivery using high-flow nasal cannula (HFNC) devices has become a popular route of aerosol administration in toddlers. Clinically, albuterol is administered using an infusion pump or unit doses. However, little evidence is available to compare the two administration strategies.

METHODS:

A toddler manikin (15 kg) with appropriate anatomic airway was connected with collecting filter to a simulator of distressed breathing. HFNC device with mesh nebulizer placed at the inlet of a humidifier at 37°C, with the gas flow set at 25 and 3.75 L/min. Five milligrams of albuterol was delivered in all experiments. With infusion pump administration, albuterol concentrations of 5 and 1 mg/mL were delivered at 4 and 20 mL/hr for 15 minutes. With unit dose administration, 1 mL (5 mg/mL) and 2 mL (2.5 mg/mL) of albuterol were nebulized. Additional tests with mouth open and nebulizers via mask were using 5 mg/1 mL for mesh nebulizer and 5 mg/3 mL for jet nebulizer (n = 3). The drug was eluted from the filter and assayed with UV spectrophotometry (276 nm).

RESULTS:

The inhaled dose was higher with unit dose than infusion pump administration with gas flows of 25 L/min (2.66 ± 0.38 vs 1.16 ± 0.28%; P = .004) and 3.75 L/min (10.51 ± 1.29 vs 8.58 ± 0.68%; P = .025). During unit dose administration, compared with closed-mouth breathing, open-mouth breathing generated a higher inhaled dose at 3.75 L/min and lower inhaled dose at 25 L/min. Compared to the nebulizers via mask with both open and closed-mouth breathing, nebulization via HFNC at 3.75 L/min generated greater inhaled dose, while HFNC at 25 L/min generated lower inhaled dose.

CONCLUSIONS:

During transnasal aerosol delivery, the inhaled dose was higher with medication administrated using unit dose than using an infusion pump.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Bronchodilator Agents / Albuterol / Cannula Type of study: Prognostic study Limits: Child, preschool / Humans Language: English Journal: Pediatr Pulmonol Journal subject: Pediatrics Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Bronchodilator Agents / Albuterol / Cannula Type of study: Prognostic study Limits: Child, preschool / Humans Language: English Journal: Pediatr Pulmonol Journal subject: Pediatrics Year: 2020 Document Type: Article