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Seroprevalence of anti-SARS-CoV-2 IgG antibodies in children with household exposure to adults with COVID-19: Preliminary findings.
Buonsenso, Danilo; Valentini, Piero; De Rose, Cristina; Pata, Davide; Sinatti, Dario; Speziale, Domenico; Ricci, Rosalba; Carfì, Angelo; Landi, Francesco; Ferrari, Vittoria; De Maio, Flavio; Palucci, Ivana; Sanguinetti, Maurizio; Sali, Michela.
  • Buonsenso D; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario, Rome, Italy.
  • Valentini P; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
  • De Rose C; Center for Global Health Research and Studies, Università Cattolica del Sacro Cuore, Roma, Italia.
  • Pata D; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario, Rome, Italy.
  • Sinatti D; Center for Global Health Research and Studies, Università Cattolica del Sacro Cuore, Roma, Italia.
  • Speziale D; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario, Rome, Italy.
  • Ricci R; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario, Rome, Italy.
  • Carfì A; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario, Rome, Italy.
  • Landi F; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Ferrari V; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • De Maio F; Geriatrics Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Palucci I; Geriatrics Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Sanguinetti M; Medicine and Surgery, Catholic University of Rome, Rome, Italy.
  • Sali M; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Pediatr Pulmonol ; 56(6): 1374-1377, 2021 06.
Article in English | MEDLINE | ID: covidwho-1064418
Preprint
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ABSTRACT
Weather and the susceptibility of children to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still a debated question and currently a hot topic, particularly in view of important decisions regarding opening schools. Therefore, we performed this prospective analysis of anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies in children with known household exposure to SARS-CoV-2 and compared their IgG status with the other adults exposed to the index case in the same household. A total of 30 families with a documented COVID-19 index case were included. A total of 44 out of 80 household contacts (55%) of index patients had anti SARS-CoV-2 IgG antibodies. In particular, 16/27 (59,3%) adult partners had IgG antibodies compared with 28/53 (52,3%) of pediatric contacts (p > .05). Among the pediatric population, children ≥5 years of age had a similar probability of having SARS-CoV-2 IgG antibodies (21/39, 53.8%) compared to those less than 5 years old (7/14, 50%) (p > .05). Adult partners and children also had a similar probability of having SARS-CoV-2 IgG antibodies. Interestingly, 10/28 (35.7%) of children and 5/27 (18.5%) of adults with SARS-CoV-2 IgG antibodies were previously diagnosed as COVID-19 cases. Our study shows evidence of a high rate of IgG antibodies in children exposed to SARS-CoV-2. This report has public health implications, highlighting the need to establish appropriate guidelines for school openings and other social activities related to childhood.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Child / Child, preschool / Humans / Infant / Middle aged / Infant, Newborn Language: English Journal: Pediatr Pulmonol Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: Ppul.25280

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Child / Child, preschool / Humans / Infant / Middle aged / Infant, Newborn Language: English Journal: Pediatr Pulmonol Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: Ppul.25280