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COVID-19 pneumonia treated with ultra-low doses of radiotherapy (ULTRA-COVID study): a single institution report of two cases.
Moreno-Olmedo, Elena; Suárez-Gironzini, Vladimir; Pérez, Manuel; Filigheddu, Teresa; Mínguez, Cristina; Sanjuan-Sanjuan, Alba; González, José A; Rivas, Daniel; Gorospe, Luis; Larrea, Luis; López, Escarlata.
  • Moreno-Olmedo E; Department of Radiation Oncology, La Milagrosa Hospital, GenesisCare, Madrid, Spain. escarlata.lopez@genesiscare.es.
  • Suárez-Gironzini V; Department of Radiation Oncology, La Milagrosa Hospital, GenesisCare, Madrid, Spain.
  • Pérez M; Department of Internal Medicine, La Milagrosa Hospital, Madrid, Spain.
  • Filigheddu T; Department of Internal Medicine, La Milagrosa Hospital, Madrid, Spain.
  • Mínguez C; Department of Radiophysics, La Milagrosa Hospital, GenesisCare, Madrid, Spain.
  • Sanjuan-Sanjuan A; Oral and Maxillofacial Surgeon, Universtiy Hospital Reina Sofía, Córdoba, Spain.
  • González JA; Department of Radiation Oncology, GenesisCare, Seville, Spain.
  • Rivas D; Department of Radiation Oncology, GenesisCare, Málaga, Spain.
  • Gorospe L; Department of Radiodiagnosis, La Milagrosa Hospital, Madrid, Spain.
  • Larrea L; Department of Radiation Oncology, Vithas Valencia Consuelo Hospital, Valencia, Spain.
  • López E; Department of Radiation Oncology, La Milagrosa Hospital, GenesisCare, Madrid, Spain.
Strahlenther Onkol ; 197(5): 429-437, 2021 05.
Article in English | MEDLINE | ID: covidwho-1064440
ABSTRACT

INTRODUCTION:

Since the outbreak of coronavirus disease 2019 (COVID-19) pandemic, healthcare systems have focused their efforts into finding a treatment to avoid the fatal outcomes of severe acute respiratory syndrome due to coronavirus­2 (SARS-CoV-2). Benefits and risks of systemic treatments remain unclear, with multiple clinical trials still ongoing. Radiotherapy could playrole in reducing the inflammatory response in the lungs and relieve life-threatening symptoms.

METHODS:

We designed a prospective study of Ultra-Low Doses of Therapy with Radiation Applied to COVID-19 (ULTRA-COVID) for patients who suffer pneumonia, are not candidates for invasive mechanical ventilation and show no improvement with medical therapy.

RESULTS:

We present the preliminary results of two patients diagnosed with COVID-19 pneumonia treated with ULTRA-COVID. After one radiotherapy session, significant clinical response and a good radiological response was observed in both cases, resulting in both patients being discharged from hospital in less than 2 weeks after radiation treatment.

CONCLUSION:

Preliminary clinical and radiological results suggest a potential benefit of treating COVID-19 pneumonia with ULTRA-COVID. ClinicalTrials.gov Identifier NCT04394182.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report / Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Strahlenther Onkol Journal subject: Neoplasms / Radiotherapy Year: 2021 Document Type: Article Affiliation country: S00066-020-01743-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Case report / Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Strahlenther Onkol Journal subject: Neoplasms / Radiotherapy Year: 2021 Document Type: Article Affiliation country: S00066-020-01743-4