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Chinese herbal medicine reduces mortality in patients with severe and critical Coronavirus disease 2019: a retrospective cohort study.
Chen, Guohua; Su, Wen; Yang, Jiayao; Luo, Dan; Xia, Ping; Jia, Wen; Li, Xiuyang; Wang, Chuan; Lang, Suping; Meng, Qingbin; Zhang, Ying; Ke, Yuhe; Fan, An; Yang, Shuo; Zheng, Yujiao; Fan, Xuepeng; Qiao, Jie; Lian, Fengmei; Wei, Li; Tong, Xiaolin.
  • Chen G; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China.
  • Su W; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China.
  • Yang J; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China.
  • Luo D; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China.
  • Xia P; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China.
  • Jia W; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China.
  • Li X; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
  • Wang C; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China.
  • Lang S; GCP ClinPlus Co., Ltd., Beijing, 100160, China.
  • Meng Q; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China.
  • Zhang Y; Beijing University of Chinese Medicine, Beijing, 100029, China.
  • Ke Y; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China.
  • Fan A; GCP ClinPlus Co., Ltd., Beijing, 100160, China.
  • Yang S; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China.
  • Zheng Y; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
  • Fan X; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China.
  • Qiao J; Hubei University of Traditional Chinese Medicine, Wuhan, 430060, China.
  • Lian F; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China. lfm565@sohu.com.
  • Wei L; Wuhan No.1 Hospital (Wuhan Integrated TCM & Western Medicine Hospital), Wuhan, 430022, China. y077088@sina.com.
  • Tong X; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China. tongxiaolin@vip.163.com.
Front Med ; 14(6): 752-759, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-1064591
ABSTRACT
This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20, 2020. All patients were divided into an exposed group (CHM users) and a control group (non-users). After propensity score matching in a 11 ratio, 156 CHM users were matched by propensity score to 156 non-users. No significant differences in seven baseline clinical variables were found between the two groups of patients. All-cause mortality was reported in 13 CHM users who died and 36 non-users who died. After multivariate adjustment, the mortality risk of CHM users was reduced by 82.2% (odds ratio 0.178, 95% CI 0.076-0.418; P < 0.001) compared with the non-users. Secondly, age (odds ratio 1.053, 95% CI 1.023-1.084; P < 0.001) and the proportion of severe/critical patients (odds ratio 0.063, 95% CI 0.028-0.143; P < 0.001) were the risk factors of mortality. These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drugs, Chinese Herbal / COVID-19 / COVID-19 Drug Treatment / Medicine, Chinese Traditional Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Traditional medicine Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Front Med Year: 2020 Document Type: Article Affiliation country: S11684-020-0813-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drugs, Chinese Herbal / COVID-19 / COVID-19 Drug Treatment / Medicine, Chinese Traditional Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Traditional medicine Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Front Med Year: 2020 Document Type: Article Affiliation country: S11684-020-0813-6