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False-negative testing for severe acute respiratory syndrome coronavirus 2: consideration in obstetrical care.
Kelly, Jeannie C; Dombrowksi, Michael; O'Neil-Callahan, Micaela; Kernberg, Annessa S; Frolova, Antonina I; Stout, Molly J.
  • Kelly JC; Division of Maternal-Fetal Medicine, Washington University in St Louis, St Louis, MO.
  • Dombrowksi M; Division of Maternal-Fetal Medicine, Washington University in St Louis, St Louis, MO.
  • O'Neil-Callahan M; Affinia Healthcare, St Louis, MO.
  • Kernberg AS; Division of Maternal-Fetal Medicine, Washington University in St Louis, St Louis, MO.
  • Frolova AI; Division of Maternal-Fetal Medicine, Washington University in St Louis, St Louis, MO.
  • Stout MJ; Division of Maternal-Fetal Medicine, Washington University in St Louis, St Louis, MO.
Am J Obstet Gynecol MFM ; 2(3): 100130, 2020 08.
Article in English | MEDLINE | ID: covidwho-1064733
ABSTRACT
Because the obstetrical population seems to have a high proportion of asymptomatic patients who are carriers of severe acute respiratory syndrome coronavirus 2, universal testing has been proposed as a strategy to risk-stratify all obstetrical admissions and guide infection prevention protocols. Here, we describe a case of a critically ill obstetrical patient with all the clinical symptoms of coronavirus disease 2019 and 3 false-negative results of nasopharyngeal swabs for molecular testing. We review and discuss the uncertain clinical characteristics of current severe acute respiratory syndrome coronavirus 2 molecular testing and the implications of false-negative results in the obstetrical population.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Obstetrics and Gynecology Department, Hospital / Bronchoalveolar Lavage Fluid / Infection Control / False Negative Reactions / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Case report / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Pregnancy Language: English Journal: Am J Obstet Gynecol MFM Year: 2020 Document Type: Article Affiliation country: J.ajogmf.2020.100130

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Obstetrics and Gynecology Department, Hospital / Bronchoalveolar Lavage Fluid / Infection Control / False Negative Reactions / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Case report / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Pregnancy Language: English Journal: Am J Obstet Gynecol MFM Year: 2020 Document Type: Article Affiliation country: J.ajogmf.2020.100130