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Understanding the genetic contribution of the human leukocyte antigen system to common major psychiatric disorders in a world pandemic context.
Tamouza, Ryad; Krishnamoorthy, Rajagopal; Leboyer, Marion.
  • Tamouza R; Université Paris Est Créteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie Translationnelle, F-94010 Creteil, France; AP-HP, Hopital Henri Mondor, Département Medico-Universitaire de Psychiatrie et d'Addictologie (DMU ADAPT), F-94010, France; Fondation FondaMental, Créteil, France. Electronic address: tamouza.ryad@gmail.com.
  • Krishnamoorthy R; Fondation FondaMental, Créteil, France.
  • Leboyer M; Université Paris Est Créteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie Translationnelle, F-94010 Creteil, France; AP-HP, Hopital Henri Mondor, Département Medico-Universitaire de Psychiatrie et d'Addictologie (DMU ADAPT), F-94010, France; Fondation FondaMental, Créteil, France.
Brain Behav Immun ; 91: 731-739, 2021 01.
Article in English | MEDLINE | ID: covidwho-1064859
ABSTRACT
The human leukocyte antigen (HLA) is a complex genetic system that encodes proteins which predominantly regulate immune/inflammatory processes. It can be involved in a variety of immuno-inflammatory disorders ranging from infections to autoimmunity and cancers. The HLA system is also suggested to be involved in neurodevelopment and neuroplasticity, especially through microglia regulation and synaptic pruning. Consequently, this highly polymorphic gene region has recently emerged as a major player in the etiology of several major psychiatric disorders, such as schizophrenia, autism spectrum disorder and bipolar disorder and with less evidence for major depressive disorders and attention deficit hyperactivity disorder. We thus review here the role of HLA genes in particular subgroups of psychiatric disorders and foresee their potential implication in future research. In particular, given the prominent role that the HLA system plays in the regulation of viral infection, this review is particularly timely in the context of the Covid-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / HLA Antigens / Mental Disorders Type of study: Etiology study / Observational study / Qualitative research Limits: Humans Language: English Journal: Brain Behav Immun Journal subject: Allergy and Immunology / Brain / Psychophysiology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / HLA Antigens / Mental Disorders Type of study: Etiology study / Observational study / Qualitative research Limits: Humans Language: English Journal: Brain Behav Immun Journal subject: Allergy and Immunology / Brain / Psychophysiology Year: 2021 Document Type: Article