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Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study.
Zhou, Jingqi; Liu, Chang; Sun, Yitang; Huang, Weishan; Ye, Kaixiong.
  • Zhou J; Department of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, USA; School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
  • Liu C; Department of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, USA; College of Life Sciences, Wuhan University, Wuhan, PR China.
  • Sun Y; Department of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, USA.
  • Huang W; Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
  • Ye K; Department of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, USA; Institute of Bioinformatics, University of Georgia, Athens, GA, USA. Electronic address: Kaixiong.Ye@uga.edu.
Brain Behav Immun ; 91: 383-392, 2021 01.
Article in English | MEDLINE | ID: covidwho-1064861
ABSTRACT

INTRODUCTION:

Our understanding of risk factors for COVID­19, including pre-existing medical conditions and genetic variations, is limited. To what extent the pre-existing clinical condition and genetic background have implications for COVID-19 still needs to be explored.

METHODS:

Our study included 389,620 participants of European descent from the UK Biobank, of whom 3,884 received the COVID-19 test and 1,091 were tested positive for COVID-19. We examined the association of COVID-19 status with an extensive list of 974 medical conditions and 30 blood biomarkers. Additionally, we tested the association of genetic variants in two key genes related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2), with COVID-19 or any other phenotypes.

RESULTS:

The most significant risk factors for COVID-19 include Alzheimer's disease (OR = 2.29, 95% CI 1.25-4.16), dementia (OR = 2.16, 95% CI 1.36-3.42), and the overall category of delirium, dementia, amnestic and other cognitive disorders (OR = 1.90, 95% CI 1.24-2.90). Evidence suggesting associations of genetic variants in SARS-CoV-2 infection-related genes with COVID-19 (rs7282236, OR = 1.33, 95% CI 1.14-1.54, p = 2.31 × 10-4) and other phenotypes, such as an immune deficiency (p = 5.65 × 10-5) and prostate cancer (p = 1.1 × 10-5), was obtained.

CONCLUSIONS:

Our unbiased and extensive search identified pre-existing Alzheimer's disease and dementia as top risk factors for hospital admission due to COVID-19, highlighting the importance of providing special protective care for patients with cognitive disorders during this pandemic. We also obtained evidence suggesting a direct association of genetic variants with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cognitive Dysfunction / COVID-19 / Hospitalization Type of study: Cohort study / Observational study / Prognostic study Topics: Variants Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Brain Behav Immun Journal subject: Allergy and Immunology / Brain / Psychophysiology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cognitive Dysfunction / COVID-19 / Hospitalization Type of study: Cohort study / Observational study / Prognostic study Topics: Variants Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Brain Behav Immun Journal subject: Allergy and Immunology / Brain / Psychophysiology Year: 2021 Document Type: Article