Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2.
Cell Calcium
; 94: 102360, 2021 03.
Article
in English
| MEDLINE | ID: covidwho-1064903
ABSTRACT
Ion channels are necessary for correct lysosomal function including degradation of cargoes originating from endocytosis. Almost all enveloped viruses, including coronaviruses (CoVs), enter host cells via endocytosis, and do not escape endosomal compartments into the cytoplasm (via fusion with the endolysosomal membrane) unless the virus-encoded envelope proteins are cleaved by lysosomal proteases. With the ongoing outbreak of severe acute respiratory syndrome (SARS)-CoV-2, endolysosomal two-pore channels represent an exciting and emerging target for antiviral therapies. This review focuses on the latest knowledge of the effects of lysosomal ion channels on the cellular entry and uncoating of enveloped viruses, which may aid in development of novel therapies against emerging infectious diseases such as SARS-CoV-2.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Virus Internalization
/
Virus Uncoating
/
Viral Envelope
/
SARS-CoV-2
/
COVID-19
/
Ion Channels
/
Lysosomes
Limits:
Humans
Language:
English
Journal:
Cell Calcium
Year:
2021
Document Type:
Article
Affiliation country:
J.ceca.2021.102360
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