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Influenza infection, SARS, MERS and COVID-19: Cytokine storm - The common denominator and the lessons to be learned.
Ryabkova, Varvara A; Churilov, Leonid P; Shoenfeld, Yehuda.
  • Ryabkova VA; Laboratory of the Mosaics of Autoimmunity, Saint Petersburg State University, Saint-Petersburg, Russian Federation.
  • Churilov LP; Laboratory of the Mosaics of Autoimmunity, Saint Petersburg State University, Saint-Petersburg, Russian Federation.
  • Shoenfeld Y; Laboratory of the Mosaics of Autoimmunity, Saint Petersburg State University, Saint-Petersburg, Russian Federation; Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Tel-Aviv University School of Medicine, Tel-Hashomer, Israel. Electronic address: shoenfel@post.tau.ac.il.
Clin Immunol ; 223: 108652, 2021 02.
Article in English | MEDLINE | ID: covidwho-1064949
ABSTRACT
The outbreak of COVID-19 reminds us that the emerging and reemerging respiratory virus infections pose a continuing threat to human life. Cytokine storm syndromes of viral origin seem to have a common pathogenesis of the imbalanced immune response with the exaggerated inflammatory reaction combined with the reduction and functional exhaustion of T cells. Immunomodulatory therapy is gaining interest in COVID-19, but this strategy has received less attention in other respiratory viral infections than it deserved. In this review we suggest that based on the similarities of the immune dysfunction in the severe cases of different respiratory viral infections, some lessons from the immunomodulatory therapy of COVID-19 (particularly regarding the choice of an immunomodulatory drug, the selection of patients and optimal time window for this kind of therapy) could be applied for some cases of severe influenza infection and probably for some future outbreaks of novel severe respiratory viral infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Orthomyxoviridae / Coronavirus Infections / Severe Acute Respiratory Syndrome / Severe acute respiratory syndrome-related coronavirus / Influenza, Human / Middle East Respiratory Syndrome Coronavirus / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Immunotherapy Limits: Humans Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Orthomyxoviridae / Coronavirus Infections / Severe Acute Respiratory Syndrome / Severe acute respiratory syndrome-related coronavirus / Influenza, Human / Middle East Respiratory Syndrome Coronavirus / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Immunotherapy Limits: Humans Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article