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A Critical Appraisal of the Effects of Anesthetics on Immune-system Modulation in Critically Ill Patients With COVID-19.
Chalkias, Athanasios; Barreto, Erin F; Laou, Eleni; Kolonia, Konstantina; Scheetz, Marc H; Gourgoulianis, Konstantinos; Pantazopoulos, Ioannis; Xanthos, Theodoros.
  • Chalkias A; Faculty of Medicine, Department of Anesthesiology, School of Health Sciences, University of Thessaly, Larisa, Greece. Electronic address: thanoschalkias@yahoo.gr.
  • Barreto EF; Department of Pharmacy, Mayo Clinic, Rochester, MN, USA; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
  • Laou E; Faculty of Medicine, Department of Anesthesiology, School of Health Sciences, University of Thessaly, Larisa, Greece.
  • Kolonia K; Faculty of Medicine, Department of Anesthesiology, School of Health Sciences, University of Thessaly, Larisa, Greece.
  • Scheetz MH; Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA; Pharmacometrics Center of Excellence, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, USA; Department of Pharmacology, College of Graduate Studies, Midwestern Universit
  • Gourgoulianis K; Faculty of Medicine, Department of Respiratory Medicine, School of Health Sciences, University of Thessaly, Larisa, Greece.
  • Pantazopoulos I; Faculty of Medicine, Department of Emergency Medicine, School of Health Sciences, University of Thessaly, Larisa, Greece.
  • Xanthos T; European University Cyprus, School of Medicine, Nicosia, Cyprus.
Clin Ther ; 43(3): e57-e70, 2021 03.
Article in English | MEDLINE | ID: covidwho-1064962
ABSTRACT

PURPOSE:

The aim of the present article was to briefly summarize current knowledge about the immunomodulatory effects of general anesthetics and the possible clinical effects of this immunomodulation in patients with COVID-19.

METHODS:

The PubMed, Scopus, and Google Scholar databases were comprehensively searched for relevant studies.

FINDINGS:

The novel coronavirus causes a wide spectrum of clinical manifestations, with a large absolute number of patients experiencing severe pneumonia and rapid progression to acute respiratory distress syndrome and multiple organ failure. In these patients, the equilibrium of the inflammatory response is a major determinant of survival. The impact of anesthetics on immune-system modulation may vary and includes both pro-inflammatory and anti-inflammatory effects. IMPLICATIONS Inhibition of the development of severe inflammation and/or the enhancement of inflammation resolution by anesthetics may limit organ damage and improve outcomes in patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Immune System / Anesthetics Type of study: Experimental Studies / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Clin Ther Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Immune System / Anesthetics Type of study: Experimental Studies / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Clin Ther Year: 2021 Document Type: Article