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RNAi therapeutics: an antiviral strategy for human infections.
Kelleher, Anthony D; Cortez-Jugo, Christina; Cavalieri, Francesca; Qu, Yijiao; Glanville, Allan R; Caruso, Frank; Symonds, Geoff; Ahlenstiel, Chantelle L.
  • Kelleher AD; Kirby Institute, UNSW, NSW, 2052, Australia.
  • Cortez-Jugo C; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
  • Cavalieri F; RMIT, Melbourne, VIC, Australia.
  • Qu Y; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
  • Glanville AR; St Vincent's Hospital, Sydney, NSW, Australia.
  • Caruso F; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and the Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
  • Symonds G; CSL, Sydney, NSW, Australia.
  • Ahlenstiel CL; Kirby Institute, UNSW, NSW, 2052, Australia. Electronic address: cahlenstiel@kirby.unsw.edu.au.
Curr Opin Pharmacol ; 54: 121-129, 2020 10.
Article in English | MEDLINE | ID: covidwho-1064979
ABSTRACT
Gene silencing induced by RNAi represents a promising antiviral development strategy. This review will summarise the current state of RNAi therapeutics for treating acute and chronic human virus infections. The gene silencing pathways exploited by RNAi therapeutics will be described and include both classic RNAi, inducing cytoplasmic mRNA degradation post-transcription and novel RNAi, mediating epigenetic modifications at the transcription level in the nucleus. Finally, the challenge of delivering gene modifications via RNAi will be discussed, along with the unique characteristics of respiratory versus systemic administration routes to highlight recent advances and future potential of RNAi antiviral treatment strategies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / RNAi Therapeutics Limits: Animals / Humans Language: English Journal: Curr Opin Pharmacol Journal subject: Pharmacology Year: 2020 Document Type: Article Affiliation country: J.coph.2020.09.011

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / RNAi Therapeutics Limits: Animals / Humans Language: English Journal: Curr Opin Pharmacol Journal subject: Pharmacology Year: 2020 Document Type: Article Affiliation country: J.coph.2020.09.011