Differential diagnosis and prospective grading of COVID-19 at the early stage with simple hematological and biochemical variables.
Diagn Microbiol Infect Dis
; 99(2): 115169, 2021 Feb.
Article
in English
| MEDLINE | ID: covidwho-1064997
ABSTRACT
We evaluated simple laboratory variables to discriminate COVID-19 from bacterial pneumonia or influenza and for the prospective grading of COVID-19. Multivariate logistic regression and receiver operating characteristic curve were used to estimate the diagnostic performance of the significant discriminating variables. A comparative analysis was performed with different severity. The leukocytosis (Pâ¯=â¯0.017) and eosinopenia (Pâ¯=â¯0.001) were discriminating variables between COVID-19 and bacterial pneumonia with area under the curve (AUC) of 0.778 and 0.825. Monocytosis (Pâ¯=â¯0.003), the decreased lymphocyte-to-monocyte ratio (Pâ¯<â¯0.001), and the increased neutrophil-to-lymphocyte ratio (NLR) (Pâ¯=â¯0.028) were predictive of influenza with AUC of 0.723, 0.895, and 0.783, respectively. Serum amyloid protein, lactate dehydrogenase, CD3+ cells, and the fibrinogen degradation products had a good correlation with the severity of COVID-19 graded by age (≥50) and NLR (≥3.13). Simple laboratory variables are helpful for rapid diagnosis on admission and hierarchical management of COVID-19 patients.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Severity of Illness Index
/
Pneumonia, Bacterial
/
Influenza, Human
/
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
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Male
/
Middle aged
/
Young adult
Language:
English
Journal:
Diagn Microbiol Infect Dis
Year:
2021
Document Type:
Article
Affiliation country:
J.diagmicrobio.2020.115169
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