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Prospective clinical validation of 3D printed nasopharyngeal swabs for diagnosis of COVID-19.
Oland, Gabriel; Garner, Omai; de St Maurice, Annabelle.
  • Oland G; UCLA David Geffen School of Medicine, Department of Surgery, Division of General Surgery, Los Angeles, CA, USA. Electronic address: GOland@mednet.ucla.edu.
  • Garner O; UCLA, Department of Pathology and Laboratory Medicine, Los Angeles, CA, USA. Electronic address: OGarner@mednet.ucla.edu.
  • de St Maurice A; UCLA David Geffen School of Medicine, Department of Pediatrics, Division of Infectious Disease, Los Angeles, CA, USA. Electronic address: AdeStMaurice@mednet.ucla.edu.
Diagn Microbiol Infect Dis ; 99(3): 115257, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-1065002
ABSTRACT
COVID-19 greatly disrupted the global supply chain of nasopharyngeal swabs, and thus new products have come to market with little data to support their use. In this prospective study, 2 new 3D printed nasopharyngeal swab designs were evaluated against the standard, flocked nasopharyngeal swab for the diagnosis of COVID-19. Seventy adult patients (37 COVID-positive and 33 COVID-negative) underwent consecutive diagnostic reverse transcription polymerase chain reaction testing, with a flocked swab followed by one or two 3D printed swabs. The "Lattice Swab" (manufacturer Resolution Medical) demonstrated 93.3% sensitivity (95% CI, 77.9%-99.2%) and 96.8% specificity (83.3%-99.9%), yielding κ = 0.90 (0.85-0.96). The "Origin KXG" (manufacturer Origin Laboratories) demonstrated 83.9% sensitivity (66.3%-94.6%) and 100% specificity (88.8%-100.0%), yielding κ = 0.84 (0.77-0.91). Both 3D printed nasopharyngeal swab results have high concordance with the control swab results. The decision to use 3D printed nasopharyngeal swabs during the COVID-19 pandemic should be strongly considered by clinical and research laboratories.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Specimen Handling / Nasopharynx / Printing, Three-Dimensional / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Diagn Microbiol Infect Dis Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Specimen Handling / Nasopharynx / Printing, Three-Dimensional / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Diagn Microbiol Infect Dis Year: 2021 Document Type: Article