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Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools.
Xiong, Haijun; Dong, Zhaowei; Lou, Guanhua; Gan, Qingxia; Wang, Jin; Huang, Qinwan.
  • Xiong H; Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Dong Z; Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Lou G; Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Gan Q; Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Wang J; Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Huang Q; Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Eur J Integr Med ; 40: 101241, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-1065081
ABSTRACT

INTRODUCTION:

The novel coronavirus pneumonia that broke out in 2019 has become a global epidemic. According to the diagnosis and treatment plan issued in China and the existing clinical data, Shufeng Jiedu (SFJD) Capsule can be effectively used in the treatment of COVID-19 patients. This study aimed to explore its mechanism of action by network pharmacology and molecular docking technology.

METHODS:

The Chinese Medicine System Pharmacology Analysis Platform (TCMSP), a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine (BATMAN-TCM), the Encyclopedia of Traditional Chinese Medicine (ETCM) and related literature records were used to search the composition and main active compounds of SFJD, and to screen out the targets of drug components. Disease-associated genes were obtained by the Human Gene Database (GeneCards), the Human Online Mendelian Inheritance Platform (OMIM) and the DisGeNET database, and the co-targeted genes/proteins as targets of both SFJD and COVID-19 were selected by the Comparative Toxicogenomics Database (CTD). Co-targeted genes/proteins were analyzed by STRING, the Database for Annotation, Visualization and Integrated Discovery (DAVID) and Reactome for proteins to protein interaction (PPI), pathway and GO (gene ontology) enrichment, and predicted by AutoDock for their high-precision docking simulation. In addition, the therapeutic effect for SFJD treatment on COVID-19 was validated by the Chinese medicine anti-novel coronavirus pneumonia drug effect prediction and analysis platform (TCMCOVID).

RESULTS:

Screening resulted in 163 compounds and 463 targeted genes. The PPI core network contains 76 co-targeted proteins. The Reactome pathways were enriched in signaling by interleukins, immune system, etc. Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol.

CONCLUSION:

SFJD may play a role in the prevention and treatment of COVID-19 through multiple active compounds acting on multiple targets and then multiple pathways.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Topics: Traditional medicine Language: English Journal: Eur J Integr Med Year: 2020 Document Type: Article Affiliation country: J.eujim.2020.101241

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study Topics: Traditional medicine Language: English Journal: Eur J Integr Med Year: 2020 Document Type: Article Affiliation country: J.eujim.2020.101241