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The role of NO in COVID-19 and potential therapeutic strategies.
Fang, Wanyi; Jiang, Jingrui; Su, Lei; Shu, Tong; Liu, Huan; Lai, Shenghan; Ghiladi, Reza A; Wang, Jun.
  • Fang W; National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Wuhan, Hubei, China; Department of Biomedicine and Biopharmacology, Hubei University of Technology, Wuhan, Hubei, China.
  • Jiang J; National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Wuhan, Hubei, China; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Su L; School of Biomedical Engineering, Shenzhen University, Shenzhen, Guangdong, China.
  • Shu T; School of Biomedical Engineering, Shenzhen University, Shenzhen, Guangdong, China.
  • Liu H; National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Wuhan, Hubei, China; Department of Biomedicine and Biopharmacology, Hubei University of Technology, Wuhan, Hubei, China.
  • Lai S; Johns Hopkins University School of Medicine, Maryland, USA.
  • Ghiladi RA; Department of Chemistry, North Carolina State University, North Carolina, USA.
  • Wang J; National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Wuhan, Hubei, China; Department of Biomedicine and Biopharmacology, Hubei University of Technology, Wuhan, Hubei, China. Electronic address: jun_wang@hbut.edu.cn.
Free Radic Biol Med ; 163: 153-162, 2021 02 01.
Article in English | MEDLINE | ID: covidwho-1065088
ABSTRACT
Nitric oxide (NO) is a free radical playing an important pathophysiological role in cardiovascular and immune systems. Recent studies reported that NO levels were significantly lower in patients with COVID-19, which was suggested to be closely related to vascular dysfunction and immune inflammation among them. In this review, we examine the potential role of NO during SARS-CoV-2 infection from the perspective of the unique physical, chemical and biological properties and potential mechanisms of NO in COVID-19, as well as possible therapeutic strategies using inhaled NO. We also discuss the limits of NO treatment, and the future application of this approach in prevention and therapy of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / COVID-19 Drug Treatment / Lung / Anti-Inflammatory Agents / Anticoagulants / Nitric Oxide Type of study: Prognostic study Limits: Humans Language: English Journal: Free Radic Biol Med Journal subject: Biochemistry / Medicine Year: 2021 Document Type: Article Affiliation country: J.freeradbiomed.2020.12.008

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / COVID-19 Drug Treatment / Lung / Anti-Inflammatory Agents / Anticoagulants / Nitric Oxide Type of study: Prognostic study Limits: Humans Language: English Journal: Free Radic Biol Med Journal subject: Biochemistry / Medicine Year: 2021 Document Type: Article Affiliation country: J.freeradbiomed.2020.12.008