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Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome.
Vita, Serena; Di Bari, Virginia; Corpolongo, Angela; Goletti, Delia; Espinosa, Joaquin; Petracca, Sebastiano; Palmieri, Fabrizio; Nicastri, Emanuele.
  • Vita S; National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Via Portuense, 292, Rome 00149, Italy.
  • Di Bari V; National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Via Portuense, 292, Rome 00149, Italy.
  • Corpolongo A; National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Via Portuense, 292, Rome 00149, Italy. Electronic address: angela.corpolongo@inmi.it.
  • Goletti D; National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Via Portuense, 292, Rome 00149, Italy.
  • Espinosa J; Linda Crnic Institute for Down Syndrome, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  • Petracca S; Clinical Institute of Casalpalocco, Intensive Care Unit, Rome 00124, Italy.
  • Palmieri F; National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Via Portuense, 292, Rome 00149, Italy.
  • Nicastri E; National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Via Portuense, 292, Rome 00149, Italy.
Int J Infect Dis ; 103: 607-610, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1065174
ABSTRACT
We report two cases of Corona Virus Disease-19 (COVID-19) in patients with Down Syndrome (DS) and describe the identification, diagnosis, clinical course and management of the infection. Down Syndrome, which is caused by trisomy 21, is characterized by immune dysregulation, anatomical differences in the upper respiratory tract and higher rate of comorbidities. All these risk factors can contribute to more severe clinical presentations of COVID-19 in this population. It is essential to raise awareness of the clinical relevance of SARS-COV-2 infection in DS patients, as well as in other most vulnerable patients, in order to improve their management and treatment and to encourage vaccinating these individuals early, once a vaccination is available.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Down Syndrome / SARS-CoV-2 / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Female / Humans / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2020.11.188

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Down Syndrome / SARS-CoV-2 / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Female / Humans / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2020.11.188