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Retrospective study identifies infection related risk factors in close contacts during COVID-19 epidemic.
Hu, Peipei; Ma, Mengmeng; Jing, Qinlong; Ma, Yu; Gan, Lin; Chen, Yan; Liu, Jundi; Wang, Dahu; Zhang, Zhoubin; Zhang, Dingmei.
  • Hu P; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
  • Ma M; Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
  • Jing Q; Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
  • Ma Y; Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
  • Gan L; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
  • Chen Y; Medical College of Shaoguan University, Shaoguan, China.
  • Liu J; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
  • Wang D; Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
  • Zhang Z; Guangzhou Center for Disease Control and Prevention, Guangzhou, China. Electronic address: gzcdczzb@gzcdc.org.cn.
  • Zhang D; Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address: zhdingm@mail.sysu.edu.cn.
Int J Infect Dis ; 103: 395-401, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1065176
ABSTRACT

OBJECTIVES:

This study aimed to compare the risk of infection of children with that of adults and to explore risk factors of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by following up close contacts of COVID-19 patients.

METHOD:

The retrospective cohort study was performed among close contacts of index cases diagnosed with COVID-19 in Guangzhou, China. Demographic characteristics, clinical symptoms and exposure information were extracted. Logistic regression analysis was employed to explore the risk factors. The restricted cubic spline was conducted to examine to the dose-response relationship between age and SARS-CoV-2 infection.

RESULTS:

The secondary attack rate (SAR) was 4.4% in 1,344 close contacts. The group of household contacts (17.2%) had the highest SAR. The rare-frequency contact (p < 0.001) and moderate-frequency contact (p < 0.001) were associated with lower risk of infection. Exposure to index cases with dry cough symptoms was associated with infection in close contacts (p = 0.004). Compared with children, adults had a significantly increased risk of infection (p = 0.014). There is a linear positive correlation between age and infection (p = 0.001).

CONCLUSIONS:

Children are probably less susceptible to COVID-19. Close contacts with frequent contact with patients and those exposed to patients with cough symptoms are associated with an increased risk of infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Child / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2020.12.011

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Child / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2020.12.011