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High prevalence of occult thrombosis in cases of mild/moderate COVID-19.
Chen, Budong; Jiang, Chunguo; Han, Bing; Guan, Chunshuang; Fang, Gaoli; Yan, Shuo; Wang, Kexin; Liu, Ligai; Conlon, Christopher P; Xie, Ruming; Song, Rui.
  • Chen B; The Radiology Department, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Jiang C; Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
  • Han B; The Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Guan C; The Radiology Department, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Fang G; Department of Otolaryngology Head and Neck Surgery, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Yan S; The Radiology Department, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Wang K; The Radiology Department, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Liu L; Center of Liver Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Conlon CP; Infectious Diseases, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Xie R; The Radiology Department, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Electronic address: mingrux@163.com.
  • Song R; The Infectious Disease Diagnostic, Therapeutic and Research Centers, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Electronic address: rui.song@ccmu.edu.cn.
Int J Infect Dis ; 104: 77-82, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-1065180
Semantic information from SemMedBD (by NLM)
1. Thrombosis COEXISTS_WITH COVID-19
Subject
Thrombosis
Predicate
COEXISTS_WITH
Object
COVID-19
2. CD69 protei ASSOCIATED_WITH C0040038
Subject
CD69 protei
Predicate
ASSOCIATED_WITH
Object
C0040038
3. CD69 protei ASSOCIATED_WITH C5203670
Subject
CD69 protei
Predicate
ASSOCIATED_WITH
Object
C5203670
4. Complication PROCESS_OF Patients
Subject
Complication
Predicate
PROCESS_OF
Object
Patients
5. Thrombus COEXISTS_WITH COVID-19
Subject
Thrombus
Predicate
COEXISTS_WITH
Object
COVID-19
6. Lung LOCATION_OF Computed Tomography Angiography
Subject
Lung
Predicate
LOCATION_OF
Object
Computed Tomography Angiography
7. Pneumonia caused by SARS-CoV-2 PROCESS_OF Patients
Subject
Pneumonia caused by SARS-CoV-2
Predicate
PROCESS_OF
Object
Patients
8. Ultrasonography ADMINISTERED_TO Patients
Subject
Ultrasonography
Predicate
ADMINISTERED_TO
Object
Patients
9. Venous Thromboembolism PROCESS_OF Patients
Subject
Venous Thromboembolism
Predicate
PROCESS_OF
Object
Patients
10. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
11. Thrombosis OCCURS_IN Patients
Subject
Thrombosis
Predicate
OCCURS_IN
Object
Patients
12. Screening procedure DIAGNOSES COVID-19
Subject
Screening procedure
Predicate
DIAGNOSES
Object
COVID-19
13. Ultrasonography DIAGNOSES Thrombosis
Subject
Ultrasonography
Predicate
DIAGNOSES
Object
Thrombosis
14. Thrombosis COEXISTS_WITH Pneumonia caused by SARS-CoV-2
Subject
Thrombosis
Predicate
COEXISTS_WITH
Object
Pneumonia caused by SARS-CoV-2
15. Thrombosis COEXISTS_WITH COVID-19
Subject
Thrombosis
Predicate
COEXISTS_WITH
Object
COVID-19
16. CD69 protein, human|CD69 ASSOCIATED_WITH Thromboembolism
Subject
CD69 protein, human|CD69
Predicate
ASSOCIATED_WITH
Object
Thromboembolism
17. CD69 protein, human|CD69 ASSOCIATED_WITH COVID-19
Subject
CD69 protein, human|CD69
Predicate
ASSOCIATED_WITH
Object
COVID-19
18. Complication PROCESS_OF Patients
Subject
Complication
Predicate
PROCESS_OF
Object
Patients
19. Thrombus COEXISTS_WITH COVID-19
Subject
Thrombus
Predicate
COEXISTS_WITH
Object
COVID-19
20. Lung LOCATION_OF Computed Tomography Angiography
Subject
Lung
Predicate
LOCATION_OF
Object
Computed Tomography Angiography
21. Pneumonia caused by SARS-CoV-2 PROCESS_OF Patients
Subject
Pneumonia caused by SARS-CoV-2
Predicate
PROCESS_OF
Object
Patients
22. Ultrasonography ADMINISTERED_TO Patients
Subject
Ultrasonography
Predicate
ADMINISTERED_TO
Object
Patients
23. Venous Thromboembolism PROCESS_OF Patients
Subject
Venous Thromboembolism
Predicate
PROCESS_OF
Object
Patients
24. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
25. Thrombosis OCCURS_IN Patients
Subject
Thrombosis
Predicate
OCCURS_IN
Object
Patients
26. Screening procedure DIAGNOSES COVID-19
Subject
Screening procedure
Predicate
DIAGNOSES
Object
COVID-19
27. Ultrasonography DIAGNOSES Thrombosis
Subject
Ultrasonography
Predicate
DIAGNOSES
Object
Thrombosis
28. Thrombosis COEXISTS_WITH Pneumonia caused by SARS-CoV-2
Subject
Thrombosis
Predicate
COEXISTS_WITH
Object
Pneumonia caused by SARS-CoV-2
ABSTRACT
BACKGROUND AND

PURPOSE:

An increasing number of reports have observed thrombosis in severe cases of COVID-19. The aim of this study was to evaluate the incidence of thromboembolism in mild/moderate cases of COVID-19. All of the patients had normal coagulation tests and none had any overt thrombotic complications. Our findings indicate that it is important to screen the thrombotic status of cases with mild/moderate COVID-19.

METHODS:

Between 11 June and 8 July 2020, 23 patients with mild/moderate COVID-19 pneumonia consented to having computed tomography pulmonary angiography (CPTA) and computed tomography venography (CTV) scans of the lungs and extremity veins. Doppler ultrasound (DUS) was also performed in all patients for screening. The incidence, clinical manifestations, laboratory examinations, imaging features, and prognosis, of patients with venous thromboembolism (VTE) were analyzed and compared with those of patients with COVID-19 pneumonia without VTE.

RESULTS:

Nineteen patients (82.6%) had VTE, mainly distal limb thrombosis. Only one of the VTE patients was positive when screened by DUS; the other VTE patients were negative by DUS. All of the mild/moderate patients with VTE were screened by CTPA + CTV. Blood tests for inflammatory, coagulation, and biochemical, parameters were all within the normal range, except for WBC and LDH.

CONCLUSIONS:

When using CTV screening for DVT, we found that the incidence of thrombosis in patients with mild/moderate COVID-19 markedly increased to 82.6% (19/23). Screening for thrombosis is therefore important in patients with COVID-19. CTV is more sensitive than DUS for the detection of thrombosis. More research is now needed to evaluate the significance of thrombosis in COVID-19 pneumonia.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Venous Thromboembolism / SARS-CoV-2 / COVID-19 Subject: Venous Thromboembolism / SARS-CoV-2 / COVID-19 Language: English Journal: Int J Infect Dis Clinical aspect: Prognosis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Venous Thromboembolism / SARS-CoV-2 / COVID-19 Subject: Venous Thromboembolism / SARS-CoV-2 / COVID-19 Language: English Journal: Int J Infect Dis Clinical aspect: Prognosis Year: 2021
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