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PD-1-Expressing SARS-CoV-2-Specific CD8+ T Cells Are Not Exhausted, but Functional in Patients with COVID-19.
Rha, Min-Seok; Jeong, Hye Won; Ko, Jae-Hoon; Choi, Seong Jin; Seo, In-Ho; Lee, Jeong Seok; Sa, Moa; Kim, A Reum; Joo, Eun-Jeong; Ahn, Jin Young; Kim, Jung Ho; Song, Kyoung-Ho; Kim, Eu Suk; Oh, Dong Hyun; Ahn, Mi Young; Choi, Hee Kyoung; Jeon, Ji Hoon; Choi, Jae-Phil; Kim, Hong Bin; Kim, Young Keun; Park, Su-Hyung; Choi, Won Suk; Choi, Jun Yong; Peck, Kyong Ran; Shin, Eui-Cheol.
  • Rha MS; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Jeong HW; Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Republic of Korea.
  • Ko JH; Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
  • Choi SJ; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Seo IH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Lee JS; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; GENOME INSIGHT Inc., Daejeon 34051, Republic of Korea.
  • Sa M; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; The Center for Epidemic Preparedness, KAIST Institute, Daejeon 34141, Republic of Korea.
  • Kim AR; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Joo EJ; Division of Infectious Diseases, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea.
  • Ahn JY; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
  • Kim JH; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
  • Song KH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Republic of Korea.
  • Kim ES; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Republic of Korea.
  • Oh DH; Department of Internal Medicine, Seoul Medical Center, Seoul 02053, Republic of Korea.
  • Ahn MY; Department of Internal Medicine, Seoul Medical Center, Seoul 02053, Republic of Korea.
  • Choi HK; Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Ansan Hospital, Ansan 15355, Republic of Korea.
  • Jeon JH; Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Ansan Hospital, Ansan 15355, Republic of Korea.
  • Choi JP; Department of Internal Medicine, Seoul Medical Center, Seoul 02053, Republic of Korea.
  • Kim HB; Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Republic of Korea.
  • Kim YK; Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju 26426, Republic of Korea.
  • Park SH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; The Center for Epidemic Preparedness, KAIST Institute, Daejeon 34141, Republic of Korea.
  • Choi WS; Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Ansan Hospital, Ansan 15355, Republic of Korea. Electronic address: cmcws@korea.ac.kr.
  • Choi JY; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea. Electronic address: seran@yuhs.ac.
  • Peck KR; Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea. Electronic address: krpeck@skku.edu.
  • Shin EC; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; The Center for Epidemic Preparedness, KAIST Institute, Daejeon 34141, Republic of Korea. Electronic address: ecshin@kaist.ac.kr.
Immunity ; 54(1): 44-52.e3, 2021 01 12.
Article in English | MEDLINE | ID: covidwho-1065202
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
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Patients
2. Exhaustion PROCESS_OF Patients
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3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
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4. Exhaustion PROCESS_OF Patients
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Exhaustion
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Patients
ABSTRACT
Memorycell responses have been demonstrated in COVID-19 convalescents, but ex vivo phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2-specific CD8+ T cells by MHC class I multimer staining and examined their phenotypes and functions in acute and convalescent COVID-19. Multimer+ cells exhibited early differentiated effector-memory phenotypes in the early convalescent phase. The frequency of stem-like memory cells was increased among multimer+ cells in the late convalescent phase. Cytokine secretion assays combined with MHC class I multimer staining revealed that the proportion of interferon-γ (IFN-γ)-producing cells was significantly lower among SARS-CoV-2-specific CD8+ T cells than those specific to influenza A virus. Importantly, the proportion of IFN-γ-producing cells was higher in PD-1+ cells than PD-1- cells among multimer+ cells, indicating that PD-1-expressing, SARS-CoV-2-specific CD8+ T cells are not exhausted, but functional. Our current findings provide information for understanding of SARS-CoV-2-specific CD8+ T cells elicited by infection or vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Programmed Cell Death 1 Receptor / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Immunity Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Programmed Cell Death 1 Receptor / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Immunity Journal subject: Allergy and Immunology Year: 2021 Document Type: Article