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Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid.
Heming, Michael; Li, Xiaolin; Räuber, Saskia; Mausberg, Anne K; Börsch, Anna-Lena; Hartlehnert, Maike; Singhal, Arpita; Lu, I-Na; Fleischer, Michael; Szepanowski, Fabian; Witzke, Oliver; Brenner, Thorsten; Dittmer, Ulf; Yosef, Nir; Kleinschnitz, Christoph; Wiendl, Heinz; Stettner, Mark; Meyer Zu Hörste, Gerd.
  • Heming M; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
  • Li X; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
  • Räuber S; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
  • Mausberg AK; Department of Neurology, University Hospital Essen, Essen, Germany.
  • Börsch AL; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
  • Hartlehnert M; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
  • Singhal A; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA.
  • Lu IN; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
  • Fleischer M; Department of Neurology, University Hospital Essen, Essen, Germany.
  • Szepanowski F; Department of Neurology, University Hospital Essen, Essen, Germany.
  • Witzke O; Department of Infectious Diseases, West German Centre of Infectious Diseases, University Duisburg-Essen, Germany.
  • Brenner T; Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
  • Dittmer U; Institute for Virology, University Hospital Essen, Germany.
  • Yosef N; Department of Electrical Engineering and Computer Science and Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
  • Kleinschnitz C; Department of Neurology, University Hospital Essen, Essen, Germany.
  • Wiendl H; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
  • Stettner M; Department of Neurology, University Hospital Essen, Essen, Germany. Electronic address: mark.stettner@uk-essen.de.
  • Meyer Zu Hörste G; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany. Electronic address: gerd.meyerzuhoerste@ukmuenster.de.
Immunity ; 54(1): 164-175.e6, 2021 01 12.
Article in English | MEDLINE | ID: covidwho-1065205
ABSTRACT
Patients suffering from Coronavirus disease 2019 (COVID-19) can develop neurological sequelae, such as headache and neuroinflammatory or cerebrovascular disease. These conditions-termed here as Neuro-COVID-are more frequent in patients with severe COVID-19. To understand the etiology of these neurological sequelae, we utilized single-cell sequencing and examined the immune cell profiles from the cerebrospinal fluid (CSF) of Neuro-COVID patients compared with patients with non-inflammatory and autoimmune neurological diseases or with viral encephalitis. The CSF of Neuro-COVID patients exhibited an expansion of dedifferentiated monocytes and of exhausted CD4+ T cells. Neuro-COVID CSF leukocytes featured an enriched interferon signature; however, this was less pronounced than in viral encephalitis. Repertoire analysis revealed broad clonal T cell expansion and curtailed interferon response in severe compared with mild Neuro-COVID patients. Collectively, our findings document the CSF immune compartment in Neuro-COVID patients and suggest compromised antiviral responses in this setting.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Monocytes / T-Lymphocytes / COVID-19 / Nervous System Diseases Type of study: Etiology study Topics: Long Covid Limits: Humans Language: English Journal: Immunity Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.immuni.2020.12.011

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Monocytes / T-Lymphocytes / COVID-19 / Nervous System Diseases Type of study: Etiology study Topics: Long Covid Limits: Humans Language: English Journal: Immunity Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.immuni.2020.12.011