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The emerging role of microRNAs in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Mirzaei, Rasoul; Mahdavi, Farzad; Badrzadeh, Fariba; Hosseini-Fard, Seyed Reza; Heidary, Maryam; Jeda, Ali Salimi; Mohammadi, Tayeb; Roshani, Mahdane; Yousefimashouf, Rasoul; Keyvani, Hossein; Darvishmotevalli, Mohammad; Sani, Melika Zarei; Karampoor, Sajad.
  • Mirzaei R; Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: rasul.micro92@gmail.com.
  • Mahdavi F; Department of Medical Parasitology and Mycology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
  • Badrzadeh F; Faculty of Medicine, Golestan University of Medical Sciences, Golestan, Iran.
  • Hosseini-Fard SR; Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Heidary M; Department of Environmental Health Engineering, Yasuj University of Medical Sciences, Yasuj, Iran.
  • Jeda AS; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Mohammadi T; Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Roshani M; Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Yousefimashouf R; Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Keyvani H; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: keyvani.h@iums.ac.ir.
  • Darvishmotevalli M; Research Center For Health, Safety And Environment (RCHSE), Alborz University of Medical Sciences, Karaj, Iran.
  • Sani MZ; Pediatric Specialist, Mashhad, Iran.
  • Karampoor S; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: sajadkarampour1987@gmail.com.
Int Immunopharmacol ; 90: 107204, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-1065215
ABSTRACT
The novel coronavirus disease 2019 (COVID-19) pandemic has imposed significant public health problems for the human populations worldwide after the 1918 influenza A virus (IVA) (H1N1) pandemic. Although numerous efforts have been made to unravel the mechanisms underlying the coronavirus, a notable gap remains in our perception of the COVID-19 pathogenesis. The innate and adaptive immune systems have a pivotal role in the fate of viral infections, such as COVID-19 pandemic. MicroRNAs (miRNAs) are known as short noncoding RNA molecules and appear as indispensable governors of almost any cellular means. Several lines of evidence demonstrate that miRNAs participate in essential mechanisms of cell biology, regulation of the immune system, and the onset and progression of numerous types of disorders. The immune responses to viral respiratory infections (VRIs), including influenza virus (IV), respiratory syncytial virus (RSV), and rhinovirus (RV), are correlated with the ectopic expression of miRNAs. Alterations of the miRNA expression in epithelial cells may contribute to the pathogenesis of chronic and acute airway infections. Hence, analyzing the role of these types of nucleotides in antiviral immune responses and the characterization of miRNA target genes might contribute to understanding the mechanisms of the interplay between the host and viruses, and in the future, potentially result in discovering therapeutic strategies for the prevention and treatment of acute COVID-19 infection. In this article, we present a general review of current studies concerning the function of miRNAs in different VRIs, particularly in coronavirus infection, and address all available therapeutic prospects to mitigate the burden of viral infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: MicroRNAs / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Animals / Humans Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: MicroRNAs / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Animals / Humans Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2021 Document Type: Article