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The role of Th17 cells in viral infections.
Aghbash, Parisa Shiri; Hemmat, Nima; Nahand, Javid Sadri; Shamekh, Ali; Memar, Mohammad Yousef; Babaei, Abouzar; Baghi, Hossein Bannazadeh.
  • Aghbash PS; Immunology Research Center, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran.
  • Hemmat N; Immunology Research Center, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran; Drug Applied Research Centre, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran.
  • Nahand JS; Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, ZIP Code 14155 Tehran, Iran; Student Research Committee, Iran University of Medical Sciences, ZIP Code 14155 Tehran, Iran.
  • Shamekh A; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran.
  • Memar MY; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran.
  • Babaei A; Department of Virology, Faculty of Medicine, Tarbiat Modares University, ZIP Code 14155 Tehran, Iran.
  • Baghi HB; Immunology Research Center, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, ZIP Code 15731 Tabriz, Iran; Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, ZI
Int Immunopharmacol ; 91: 107331, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1065225
Semantic information from SemMedBD (by NLM)
1. Virus Diseases NEG_AFFECTS Malignant Neoplasms
Subject
Virus Diseases
Predicate
NEG_AFFECTS
Object
Malignant Neoplasms
2. Virus Diseases CAUSES Chronic inflammation
Subject
Virus Diseases
Predicate
CAUSES
Object
Chronic inflammation
3. Th17 Cells PRODUCES cytokine
Subject
Th17 Cells
Predicate
PRODUCES
Object
cytokine
4. Th17 Cells PRODUCES IL17A protei
Subject
Th17 Cells
Predicate
PRODUCES
Object
IL17A protei
5. Cell Count DIAGNOSES Tumor Progression
Subject
Cell Count
Predicate
DIAGNOSES
Object
Tumor Progression
6. Cell Count DIAGNOSES Secondary Neoplasm
Subject
Cell Count
Predicate
DIAGNOSES
Object
Secondary Neoplasm
7. Virus Diseases NEG_AFFECTS Malignant Neoplasms
Subject
Virus Diseases
Predicate
NEG_AFFECTS
Object
Malignant Neoplasms
8. Virus Diseases CAUSES Chronic inflammation
Subject
Virus Diseases
Predicate
CAUSES
Object
Chronic inflammation
9. Th17 Cells PRODUCES cytokine
Subject
Th17 Cells
Predicate
PRODUCES
Object
cytokine
10. Th17 Cells PRODUCES IL17A protein, human|IL17A
Subject
Th17 Cells
Predicate
PRODUCES
Object
IL17A protein, human|IL17A
11. Cell Count DIAGNOSES Tumor Progression
Subject
Cell Count
Predicate
DIAGNOSES
Object
Tumor Progression
12. Cell Count DIAGNOSES Secondary Neoplasm
Subject
Cell Count
Predicate
DIAGNOSES
Object
Secondary Neoplasm
ABSTRACT
The present review provides an overview of recent advances regarding the function of Th17 cells and their produced cytokines in the progression of viral diseases. Viral infections alone do not lead to virus-induced malignancies, as both genetic and host safety factors are also involved in the occurrence of malignancies. Acquired immune responses, through the differentiation of Th17 cells, form the novel components of the Th17 cell pathway when reacting with viral infections all the way from the beginning to its final stages. As a result, instead of inducing the right immune responses, these events lead to the suppression of the immune system. In fact, the responses from Th17 cells during persistent viral infections causes chronic inflammation through the production of IL-17 and other cytokines which provide a favorable environment for tumor growth and its development. Additionally, during the past decade, these cells have been understood to be involved in tumor progression and metastasis. However, further research is required to understand Th17 cells' immune mechanisms in the vast variety of viral diseases. This review aims to determine the roles and effects of the immune system, especially Th17 cells, in the progression of viral diseases; which can be highly beneficial for the diagnosis and treatment of these infections.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Tumor Virus Infections / Viruses / Cell Transformation, Viral / Th17 Cells / Neoplasms Limits: Animals / Humans Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2021 Document Type: Article Affiliation country: J.intimp.2020.107331

Full text: Available Collection: International databases Database: MEDLINE Main subject: Tumor Virus Infections / Viruses / Cell Transformation, Viral / Th17 Cells / Neoplasms Limits: Animals / Humans Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2021 Document Type: Article Affiliation country: J.intimp.2020.107331