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A Potential Role of Interleukin 10 in COVID-19 Pathogenesis.
Lu, Ligong; Zhang, Hui; Dauphars, Danielle J; He, You-Wen.
  • Lu L; Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, Guangdong Province, 519000, PR China. Electronic address: luligong1969@126.com.
  • Zhang H; First Affiliated Hospital, China Medical University, Shenyang, PR China.
  • Dauphars DJ; Department of Immunology, Duke University Medical University Medical Center, Durham, NC 27710, USA.
  • He YW; Department of Immunology, Duke University Medical University Medical Center, Durham, NC 27710, USA. Electronic address: youwen.he@duke.edu.
Trends Immunol ; 42(1): 3-5, 2021 01.
Article in English | MEDLINE | ID: covidwho-1065236
Semantic information from SemMedBD (by NLM)
1. interleukin-10 ASSOCIATED_WITH COVID-19
Subject
interleukin-10
Predicate
ASSOCIATED_WITH
Object
COVID-19
2. Cytokine Storm COEXISTS_WITH COVID-19
Subject
Cytokine Storm
Predicate
COEXISTS_WITH
Object
COVID-19
3. Elevation procedure USES interleukin-10
Subject
Elevation procedure
Predicate
USES
Object
interleukin-10
4. Elevation procedure AFFECTS COVID-19
Subject
Elevation procedure
Predicate
AFFECTS
Object
COVID-19
5. interleukin-10 ASSOCIATED_WITH COVID-19
Subject
interleukin-10
Predicate
ASSOCIATED_WITH
Object
COVID-19
6. Cytokine Storm COEXISTS_WITH COVID-19
Subject
Cytokine Storm
Predicate
COEXISTS_WITH
Object
COVID-19
7. Elevation procedure USES interleukin-10
Subject
Elevation procedure
Predicate
USES
Object
interleukin-10
8. Elevation procedure AFFECTS COVID-19
Subject
Elevation procedure
Predicate
AFFECTS
Object
COVID-19
ABSTRACT
A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL-10 elevation may play a pathological role in COVID-19 severity.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Interleukin-10 / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Subject: Interleukin-10 / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Type of study: Etiology study Language: English Journal: Trends Immunol Clinical aspect: Etiology / Prognosis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Interleukin-10 / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Subject: Interleukin-10 / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Type of study: Etiology study Language: English Journal: Trends Immunol Clinical aspect: Etiology / Prognosis Year: 2021
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