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Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells.
Ahmetaj-Shala, Blerina; Vaja, Ricky; Atanur, Santosh S; George, Peter M; Kirkby, Nicholas S; Mitchell, Jane A.
  • Ahmetaj-Shala B; Cardiorespiratory Interface, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Vaja R; Cardiorespiratory Interface, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Atanur SS; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.
  • George PM; Institute of Translational Medicine and Therapeutics, Data Science Group, National Institute for Health Research, Biomedical Research Centre, Imperial College London, London, United Kingdom.
  • Kirkby NS; Cardiorespiratory Interface, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
  • Mitchell JA; Interstitial Lung Disease Unit, National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
JACC Basic Transl Sci ; 5(11): 1111-1123, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-1065247
Semantic information from SemMedBD (by NLM)
1. Endothelial Cells LOCATION_OF Antigen
Subject
Endothelial Cells
Predicate
LOCATION_OF
Object
Antigen
2. Cardiovascular LOCATION_OF vascular inflammations
Subject
Cardiovascular
Predicate
LOCATION_OF
Object
vascular inflammations
3. Thrombosis COEXISTS_WITH COVID-19
Subject
Thrombosis
Predicate
COEXISTS_WITH
Object
COVID-19
4. vascular inflammations COEXISTS_WITH COVID-19
Subject
vascular inflammations
Predicate
COEXISTS_WITH
Object
COVID-19
5. Endothelial Cells LOCATION_OF BSG gene|BSG
Subject
Endothelial Cells
Predicate
LOCATION_OF
Object
BSG gene|BSG
6. Body tissue LOCATION_OF ACE2 gene|ACE2
Subject
Body tissue
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
7. COVID-19 PREDISPOSES Severe disease
Subject
COVID-19
Predicate
PREDISPOSES
Object
Severe disease
8. Endothelial Cells LOCATION_OF Antigens, CD147
Subject
Endothelial Cells
Predicate
LOCATION_OF
Object
Antigens, CD147
9. Cardiovascular LOCATION_OF vascular inflammations
Subject
Cardiovascular
Predicate
LOCATION_OF
Object
vascular inflammations
10. Thrombosis COEXISTS_WITH COVID-19
Subject
Thrombosis
Predicate
COEXISTS_WITH
Object
COVID-19
11. vascular inflammations COEXISTS_WITH COVID-19
Subject
vascular inflammations
Predicate
COEXISTS_WITH
Object
COVID-19
12. Endothelial Cells LOCATION_OF BSG gene|BSG
Subject
Endothelial Cells
Predicate
LOCATION_OF
Object
BSG gene|BSG
13. Body tissue LOCATION_OF ACE2 gene|ACE2
Subject
Body tissue
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
14. COVID-19 PREDISPOSES Severe disease
Subject
COVID-19
Predicate
PREDISPOSES
Object
Severe disease
ABSTRACT
Vascular and cardiovascular inflammation and thrombosis occur in patients with severe coronavirus disease-2019 (COVID-19). Advancing age is the most significant risk factor for severe COVID-19. Using transcriptomic databases, the authors found that 1) cardiovascular tissues and endothelial cells express putative genes for severe acute respiratory syndrome coronavirus-2 infection, including angiotensin-converting enzyme 2 (ACE2) and basigin (BSG); 2) severe acute respiratory syndrome coronavirus-2 receptor pathways ACE2/transmembrane serine protease 2 and BSG/peptidylprolyl isomerase B(A) polarize to lung/epithelium and vessel/endothelium, respectively; 3) expression of host genes is relatively stable with age; and 4) notable exceptions are ACE2, which decreases with age in some tissues, and BSG, which increases with age in endothelial cells, suggesting that BSG expression in the vasculature may explain the heightened risk for severe disease with age.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: JACC Basic Transl Sci Year: 2020 Document Type: Article Affiliation country: J.jacbts.2020.09.010

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: JACC Basic Transl Sci Year: 2020 Document Type: Article Affiliation country: J.jacbts.2020.09.010