Ketamine's rapid antisuicidal effects are not attenuated by Buprenorphine.
J Affect Disord
; 282: 252-254, 2021 03 01.
Article
in English
| MEDLINE | ID: covidwho-1065258
ABSTRACT
Ketamine's rapid antisuicidal action has gathered significant clinical interest in treatment of depression though concerns exist that its actions occur through the Opioid pathway. A recent study additionally reported that Naltrexone blocks antisuicidal effects of Ketamine suggesting that its antisuicidal effects are also due to opioid mechanisms. We present a case of treatment refractory depression with recent suicide attempt and active suicidal ideations who was on an Opioid partial agonist, Buprenorphine, for management of pain. Patient responded to a trial of IV ketamine treatment with rapid improvement in suicidal thoughts. Patient's suicidal ideations decreased after first Ketamine treatment and resolved after second treatment while maintained on Buprenorphine. Our finding shows that Buprenorphine does not block Ketamine's effects on suicidal ideations and therefore Ketamine treatment could be provided safely in controlled environment to those with substance use disorders or with chronic pain while being maintained on Buprenorphine. Additionally, our case suggests that non-Opioid mechanisms may be involved in Ketamine's antidepressant effects and its response to suicidal ideations in those on Opioid partial agonists.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Buprenorphine
/
Depressive Disorder, Treatment-Resistant
/
Ketamine
Type of study:
Case report
/
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
J Affect Disord
Year:
2021
Document Type:
Article
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