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Association of Timing and Balance of Physical Activity and Rest/Sleep With Risk of COVID-19: A UK Biobank Study.
Rowlands, Alex V; Kloecker, David E; Chudasama, Yogini; Davies, Melanie J; Dawkins, Nathan P; Edwardson, Charlotte L; Gillies, Clare; Khunti, Kamlesh; Razieh, Cameron; Islam, Nazrul; Zaccardi, Francesco; Yates, Tom.
  • Rowlands AV; Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital Gwendolen Rd, Leicester, United Kingdom; National Institute for Health Research, Leicester Biomedical Research Centre, Leicester General Hospital, Leicester, United Kingdom. Electronic address: alex.rowlands@le.ac.uk.
  • Kloecker DE; Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital Gwendolen Rd, Leicester, United Kingdom; Leicester Real World Evidence Unit, Leicester Diabetes Centre, Leicester General Hospital, Leicester, United Kingdom.
  • Chudasama Y; Leicester Real World Evidence Unit, Leicester Diabetes Centre, Leicester General Hospital, Leicester, United Kingdom.
  • Davies MJ; Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital Gwendolen Rd, Leicester, United Kingdom; NIHR Applied Research Collaboration - East Midlands, Leicester General Hospital, Leicester, United Kingdom.
  • Dawkins NP; Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital Gwendolen Rd, Leicester, United Kingdom; National Institute for Health Research, Leicester Biomedical Research Centre, Leicester General Hospital, Leicester, United Kingdom.
  • Edwardson CL; Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital Gwendolen Rd, Leicester, United Kingdom; National Institute for Health Research, Leicester Biomedical Research Centre, Leicester General Hospital, Leicester, United Kingdom.
  • Gillies C; Leicester Real World Evidence Unit, Leicester Diabetes Centre, Leicester General Hospital, Leicester, United Kingdom.
  • Khunti K; Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital Gwendolen Rd, Leicester, United Kingdom; Leicester Real World Evidence Unit, Leicester Diabetes Centre, Leicester General Hospital, Leicester, United Kingdom; NIHR Applied Research Collaboration - East Midlands, Leiceste
  • Razieh C; Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital Gwendolen Rd, Leicester, United Kingdom; National Institute for Health Research, Leicester Biomedical Research Centre, Leicester General Hospital, Leicester, United Kingdom.
  • Islam N; Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Zaccardi F; Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital Gwendolen Rd, Leicester, United Kingdom; Leicester Real World Evidence Unit, Leicester Diabetes Centre, Leicester General Hospital, Leicester, United Kingdom.
  • Yates T; Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital Gwendolen Rd, Leicester, United Kingdom; National Institute for Health Research, Leicester Biomedical Research Centre, Leicester General Hospital, Leicester, United Kingdom.
Mayo Clin Proc ; 96(1): 156-164, 2021 01.
Article in English | MEDLINE | ID: covidwho-1065442
ABSTRACT
Behavioral lifestyle factors are associated with cardiometabolic disease and obesity, which are risk factors for coronavirus disease 2019 (COVID-19). We aimed to investigate whether physical activity, and the timing and balance of physical activity and sleep/rest, were associated with SARS-CoV-2 positivity and COVID-19 severity. Data from 91,248 UK Biobank participants with accelerometer data and complete covariate and linked COVID-19 data to July 19, 2020, were included. The risk of SARS-CoV-2 positivity and COVID-19 severity-in relation to overall physical activity, moderate-to-vigorous physical activity (MVPA), balance between activity and sleep/rest, and variability in timing of sleep/rest-was assessed with adjusted logistic regression. Of 207 individuals with a positive test result, 124 were classified as having a severe infection. Overall physical activity and MVPA were not associated with severe COVID-19, whereas a poor balance between activity and sleep/rest was (odds ratio [OR] per standard deviation 0.71; 95% confidence interval [CI], 0.62 to 0.81]). This finding was related to higher daytime activity being associated with lower risk (OR, 0.75; 95% CI, 0.61 to 0.93) but higher movement during sleep/rest being associated with higher risk (OR, 1.26; 95% CI, 1.12 to 1.42) of severe infection. Greater variability in timing of sleep/rest was also associated with increased risk (OR, 1.21; 95% CI, 1.08 to 1.35). Results for testing positive were broadly consistent. In conclusion, these results highlight the importance of not just physical activity, but also quality sleep/rest and regular sleep/rest patterns, on risk of COVID-19. Our findings indicate the risk of COVID-19 was consistently approximately 1.2-fold greater per approximately 40-minute increase in variability in timing of proxy measures of sleep, indicative of irregular sleeping patterns.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Rest / Sleep / Exercise / COVID-19 Subject: Rest / Sleep / Exercise / COVID-19 Type of study: Etiology study / Observational study / Risk factors Language: English Journal: Mayo Clin Proc Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Rest / Sleep / Exercise / COVID-19 Subject: Rest / Sleep / Exercise / COVID-19 Type of study: Etiology study / Observational study / Risk factors Language: English Journal: Mayo Clin Proc Clinical aspect: Etiology Year: 2021
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