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Hypertension is a clinically important risk factor for critical illness and mortality in COVID-19: A meta-analysis.
Du, Yanbin; Zhou, Nan; Zha, Wenting; Lv, Yuan.
  • Du Y; MOE-LCSM, School of Mathematics and Statistics, Hunan Normal University, Changsha, Hunan Province, 410081, China.
  • Zhou N; Key Laboratory of Molecular Epidemiology, Medical College of Hunan Normal University, Changsha, Hunan Province, 410013, China.
  • Zha W; Key Laboratory of Molecular Epidemiology, Medical College of Hunan Normal University, Changsha, Hunan Province, 410013, China. Electronic address: 183259829@qq.com.
  • Lv Y; Key Laboratory of Molecular Epidemiology, Medical College of Hunan Normal University, Changsha, Hunan Province, 410013, China. Electronic address: 284792906@qq.com.
Nutr Metab Cardiovasc Dis ; 31(3): 745-755, 2021 03 10.
Article in English | MEDLINE | ID: covidwho-1065508
ABSTRACT

AIMS:

As reported, hypertension may play an important role in adverse outcomes of coronavirus disease-2019 (COVID-19), but it still had many confounding factors. The aim of this study was to explore whether hypertension is an independent risk factor for critical COVID-19 and mortality. DATA

SYNTHESIS:

The Medline, PubMed, Embase, and Web of Science databases were systematically searched until November 2020. Combined odds ratios (ORs) with their 95% confidence interval (CIs) were calculated by using random-effect models, and the effect of covariates was analyzed using the subgroup analysis and meta-regression analysis. A total of 24 observational studies with 99,918 COVID-19 patients were included in the meta-analysis. The proportions of hypertension in critical COVID-19 were 37% (95% CI 0.27 -0.47) when compared with 18% (95% CI 0.14 -0.23) of noncritical COVID-19 patients, in those who died were 46% (95%CI 0.37 -0.55) when compared with 22% (95% CI 0.16 -0.28) of survivors. Pooled results based on the adjusted OR showed that patients with hypertension had a 1.82-fold higher risk for critical COVID-19 (aOR 1.82; 95% CI 1.19 - 2.77; P = 0.005) and a 2.17-fold higher risk for COVID-19 mortality (aOR 2.17; 95% CI 1.67 - 2.82; P < 0.001). Subgroup analysis results showed that male patients had a higher risk of developing to the critical condition than female patients (OR 3.04; 95%CI 2.06 - 4.49; P < 0.001) and age >60 years was associated with a significantly increased risk of COVID-19 mortality (OR 3.12; 95% CI 1.93 - 5.05; P < 0.001). Meta-regression analysis results also showed that age (Coef. = 2.3×10-2, P = 0.048) had a significant influence on the association between hypertension and COVID-19 mortality.

CONCLUSIONS:

Evidence from this meta-analysis suggested that hypertension was independently associated with a significantly increased risk of critical COVID-19 and inhospital mortality of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hypertension Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Nutr Metab Cardiovasc Dis Journal subject: Vascular Diseases / Cardiology / Nutritional Sciences / Metabolism Year: 2021 Document Type: Article Affiliation country: J.numecd.2020.12.009

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hypertension Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Nutr Metab Cardiovasc Dis Journal subject: Vascular Diseases / Cardiology / Nutritional Sciences / Metabolism Year: 2021 Document Type: Article Affiliation country: J.numecd.2020.12.009