Severe cortical damage associated with COVID-19 case report.

Zombori, Luca; Bacon, Melody; Wood, Hannah; Chatterjee, Fiona; Venkateswaran, Ramesh; Lampariello, Simona; Yoong, Michael

Zombori, Luca; Bacon, Melody; Wood, Hannah; Chatterjee, Fiona; Venkateswaran, Ramesh; Lampariello, Simona; Yoong, Michael.

Zombori L; Paediatric Critical Care Unit, Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, Whitechapel, London, E1 1FR United Kingdom. Electronic address: luca.zombori@nhs.net.
Bacon M; Paediatric Neurology, Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, Whitechapel, London, E1 1FR United Kingdom.
Wood H; Paediatric Neurology, Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, Whitechapel, London, E1 1FR United Kingdom.
Chatterjee F; Paediatric Radiology, Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, Whitechapel, London, E1 1FR United Kingdom.
Venkateswaran R; Paediatric Neurology, Kings College Healthcare NHS Trust, Stand, London, WC2R 2LS, United Kingdom.
Lampariello S; Paediatric Critical Care Unit, Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, Whitechapel, London, E1 1FR United Kingdom.
Yoong M; Paediatric Neurology, Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, Whitechapel, London, E1 1FR United Kingdom.

Seizure ; 84: 66-68, 2021 Jan.

Article in English | MEDLINE | ID: covidwho-1065590

ABSTRACT

ABSTRACT

Symptoms of COVID-19, as reported during the SARS-CoV-2 pandemic in 2019-2020, are primarily respiratory and gastrointestinal, with sparse reports on neurological manifestations. We describe the case of a 17-year old female with Cornelia de Lange syndrome and well controlled epilepsy, who sustained significant cortical injury during a COVID-19 associated multi-inflammatory syndrome.

Subject(s)

Brain Diseases/physiopathology; COVID-19/physiopathology; De Lange Syndrome/complications; Epilepsy/physiopathology; Seizures/physiopathology; Systemic Inflammatory Response Syndrome/physiopathology; Acute Kidney Injury/etiology; Adolescent; Airway Extubation; Anticonvulsants/therapeutic use; Blood Coagulation Disorders/etiology; Bone Marrow Failure Disorders; Brain Diseases/diagnostic imaging; Brain Diseases/etiology; Brain Diseases/pathology; Brain Edema/diagnostic imaging; Brain Edema/etiology; C-Reactive Protein/immunology; COVID-19/complications; COVID-19/immunology; COVID-19/therapy; Disease Progression; Electroencephalography; Epilepsy/complications; Epilepsy/drug therapy; Female; Ferritins/metabolism; Humans; Influenza B virus; Influenza, Human/complications; Levetiracetam/therapeutic use; Magnetic Resonance Imaging; Midazolam/therapeutic use; Necrosis; Phenobarbital/therapeutic use; Pseudomonas Infections/complications; Respiration, Artificial; Rhabdomyolysis/complications; Rhabdomyolysis/etiology; SARS-CoV-2; Seizures/drug therapy; Seizures/etiology; Sepsis/etiology; Sepsis/physiopathology; Sepsis/therapy; Systemic Inflammatory Response Syndrome/complications; Systemic Inflammatory Response Syndrome/immunology; Systemic Inflammatory Response Syndrome/therapy; Tachycardia, Ventricular/etiology; Tachycardia, Ventricular/physiopathology; Tachycardia, Ventricular/therapy

Keywords

COVID-19; Cornelia de Lange syndrome; Coronavirus; Cortical brain damage; Cortical injury; Seizure

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Seizures / Brain Diseases / Systemic Inflammatory Response Syndrome / De Lange Syndrome / Epilepsy / COVID-19 Type of study: Case report / Experimental Studies Topics: Long Covid Language: English Journal: Seizure Journal subject: Neurology Year: 2021 Document Type: Article

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