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Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2.
Wrobel, Antoni G; Benton, Donald J; Xu, Pengqi; Calder, Lesley J; Borg, Annabel; Roustan, Chloë; Martin, Stephen R; Rosenthal, Peter B; Skehel, John J; Gamblin, Steven J.
  • Wrobel AG; Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT, London, UK. antoni.wrobel@crick.ac.uk.
  • Benton DJ; Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT, London, UK. donald.benton@crick.ac.uk.
  • Xu P; Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT, London, UK.
  • Calder LJ; Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
  • Borg A; Structural Biology of Cells and Viruses Laboratory, Francis Crick Institute, NW1 1AT, London, UK.
  • Roustan C; Structural Biology Science Technology Platform, Francis Crick Institute, NW1 1AT, London, UK.
  • Martin SR; Structural Biology Science Technology Platform, Francis Crick Institute, NW1 1AT, London, UK.
  • Rosenthal PB; Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT, London, UK.
  • Skehel JJ; Structural Biology of Cells and Viruses Laboratory, Francis Crick Institute, NW1 1AT, London, UK.
  • Gamblin SJ; Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT, London, UK.
Nat Commun ; 12(1): 837, 2021 02 05.
Article in English | MEDLINE | ID: covidwho-1065863
ABSTRACT
Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts a fully-closed conformation and that, aside from the Receptor-Binding Domain, it resembles the spike of a bat coronavirus RaTG13 more than that of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Evolution, Molecular / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Observational study Limits: Animals / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-21006-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Evolution, Molecular / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Observational study Limits: Animals / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-21006-9