Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples.
Sci Rep
; 11(1): 3, 2021 01 08.
Article
in English
| MEDLINE | ID: covidwho-1387457
ABSTRACT
SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and SARS-CoV-2 have been shown to localize to mitochondria and disrupt Mitochondrial Antiviral Signaling (MAVS) protein signaling. Therefore, we hypothesized that SARS-CoV-2 would distinctly regulate the mitochondrial transcriptome. We analyzed multiple publicly available RNASeq data derived from primary cells, cell lines, and clinical samples (i.e., BALF and lung). We report that SARS-CoV-2 did not dramatically regulate (1) mtDNA-encoded gene expression or (2) MAVS expression, and (3) SARS-CoV-2 downregulated nuclear-encoded mitochondrial (NEM) genes related to cellular respiration and Complex I.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
DNA, Mitochondrial
/
Transcriptome
/
SARS-CoV-2
/
COVID-19
/
Mitochondria
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Sci Rep
Year:
2021
Document Type:
Article
Affiliation country:
S41598-020-79552-Z
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