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Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients.
DeKosky, Steven T; Kochanek, Patrick M; Valadka, Alex B; Clark, Robert S B; Chou, Sherry H-Y; Au, Alicia K; Horvat, Christopher; Jha, Ruchira M; Mannix, Rebekah; Wisniewski, Stephen R; Wintermark, Max; Rowell, Susan E; Welch, Robert D; Lewis, Lawrence; House, Stacey; Tanzi, Rudolph E; Smith, Darci R; Vittor, Amy Y; Denslow, Nancy D; Davis, Michael D; Glushakova, Olena Y; Hayes, Ronald L.
  • DeKosky ST; McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida, USA.
  • Kochanek PM; Department of Critical Care Medicine, Department of Anesthesiology, Pediatrics, Bioengineering, and Clinical and Translational Science, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Valadka AB; Department of Neurosurgery, Virginia Commonwealth University, Richmond, Virginia, USA.
  • Clark RSB; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Chou SH; Department of Critical Care Medicine, Neurology, and Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Au AK; University of Pittsburgh, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Horvat C; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Division of Pediatric Critical Care, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Jha RM; Departments of Critical Care Medicine, Neurology, Neurological Surgery, Clinical and Translational Science Institute, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Mannix R; Department of Pediatrics and Emergency Medicine, Harvard Medical School, Department of Medicine, Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Wisniewski SR; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Wintermark M; Department of Neuroradiology, Stanford University, Stanford, California, USA.
  • Rowell SE; Duke University School of Medicine, Durham, North Carolina, USA.
  • Welch RD; Department of Emergency Medicine, Wayne State University School of Medicine, Detroit Receiving Hospital/University Health Center, Detroit, Michigan, USA.
  • Lewis L; Department of Emergency Medicine, Washington University in St. Louis, St. Louis, Missouri, USA.
  • House S; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Tanzi RE; Genetics and Aging Research Unit, Massachusetts General Hospital, McCance Center for Brain Health, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Department of Neurology (Research), Massachusetts General Hospital, Department of N
  • Smith DR; Immunodiagnostics Department, Naval Medical Research Center, Biological Defense Research Directorate, Fort Detrick, Maryland, USA.
  • Vittor AY; Division of Infectious Disease and Global Medicine, University of Florida, Emerging Pathogens Institute, Gainesville, Florida, USA.
  • Denslow ND; Departments of Physiological Sciences and Biochemistry and Molecular Biology, University of Florida, Center for Environmental and Human Toxicology, Gainesville, Florida.
  • Davis MD; Department of Pediatrics, Wells Center for Pediatric Research/Pulmonology, Allergy, and Sleep Medicine, Riley Hospital for Children at Indiana University, Indianapolis, Indiana, USA.
  • Glushakova OY; University of Virginia Cancer Center, Charlottesville, Virginia, USA.
  • Hayes RL; Banyan Biomarkers Inc., Alachua, Florida, USA.
J Neurotrauma ; 38(1): 1-43, 2021 01 01.
Article in English | MEDLINE | ID: covidwho-1066221
Semantic information from SemMedBD (by NLM)
1. Detection TREATS Patient Physiological Condition
Subject
Detection
Predicate
TREATS
Object
Patient Physiological Condition
2. Disease PROCESS_OF hospitalized patients
Subject
Disease
Predicate
PROCESS_OF
Object
hospitalized patients
3. Central Nervous System ASSOCIATED_WITH Patient Physiological Condition
Subject
Central Nervous System
Predicate
ASSOCIATED_WITH
Object
Patient Physiological Condition
4. Diagnosis DIAGNOSES Patient Physiological Condition
Subject
Diagnosis
Predicate
DIAGNOSES
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Patient Physiological Condition
5. Diagnosis ADMINISTERED_TO Patients
Subject
Diagnosis
Predicate
ADMINISTERED_TO
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Patients
6. Communicable Diseases PROCESS_OF Patients
Subject
Communicable Diseases
Predicate
PROCESS_OF
Object
Patients
7. CNS metastases PROCESS_OF Patients
Subject
CNS metastases
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PROCESS_OF
Object
Patients
8. Therapeutic procedure TREATS Patient Physiological Condition
Subject
Therapeutic procedure
Predicate
TREATS
Object
Patient Physiological Condition
9. Detection TREATS Patient Physiological Condition
Subject
Detection
Predicate
TREATS
Object
Patient Physiological Condition
10. Disease PROCESS_OF hospitalized patients
Subject
Disease
Predicate
PROCESS_OF
Object
hospitalized patients
11. Central Nervous System ASSOCIATED_WITH Patient Physiological Condition
Subject
Central Nervous System
Predicate
ASSOCIATED_WITH
Object
Patient Physiological Condition
12. Diagnosis DIAGNOSES Patient Physiological Condition
Subject
Diagnosis
Predicate
DIAGNOSES
Object
Patient Physiological Condition
13. Diagnosis ADMINISTERED_TO Patients
Subject
Diagnosis
Predicate
ADMINISTERED_TO
Object
Patients
14. Communicable Diseases PROCESS_OF Patients
Subject
Communicable Diseases
Predicate
PROCESS_OF
Object
Patients
15. CNS metastases PROCESS_OF Patients
Subject
CNS metastases
Predicate
PROCESS_OF
Object
Patients
16. Therapeutic procedure TREATS Patient Physiological Condition
Subject
Therapeutic procedure
Predicate
TREATS
Object
Patient Physiological Condition
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple organs of coronavirus disease 2019 (COVID-19) patients, including the brain. There are worldwide descriptions of neurological deficits in COVID-19 patients. Central nervous system (CNS) symptoms can be present early in the course of the disease. As many as 55% of hospitalized COVID-19 patients have been reported to have neurological disturbances three months after infection by SARS-CoV-2. The mutability of the SARS-COV-2 virus and its potential to directly affect the CNS highlight the urgency of developing technology to diagnose, manage, and treat brain injury in COVID-19 patients. The pathobiology of CNS infection by SARS-CoV-2 and the associated neurological sequelae of this infection remain poorly understood. In this review, we outline the rationale for the use of blood biomarkers (BBs) for diagnosis of brain injury in COVID-19 patients, the research needed to incorporate their use into clinical practice, and the improvements in patient management and outcomes that can result. BBs of brain injury could potentially provide tools for detection of brain injury in COVID-19 patients. Elevations of BBs have been reported in cerebrospinal fluid (CSF) and blood of COVID-19 patients. BB proteins have been analyzed in CSF to detect CNS involvement in patients with infectious diseases, including human immunodeficiency virus and tuberculous meningitis. BBs are approved by the U.S. Food and Drug Administration for diagnosis of mild versus moderate traumatic brain injury and have identified brain injury after stroke, cardiac arrest, hypoxia, and epilepsy. BBs, integrated with other diagnostic tools, could enhance understanding of viral mechanisms of brain injury, predict severity of neurological deficits, guide triage of patients and assignment to appropriate medical pathways, and assess efficacy of therapeutic interventions in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Brain Injuries / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: J Neurotrauma Journal subject: Neurology / Traumatology Year: 2021 Document Type: Article Affiliation country: Neu.2020.7332

Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Brain Injuries / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: J Neurotrauma Journal subject: Neurology / Traumatology Year: 2021 Document Type: Article Affiliation country: Neu.2020.7332