Iodine allergy: Common misperceptions.
Am J Health Syst Pharm
; 78(9): 781-793, 2021 04 22.
Article
in English
| MEDLINE | ID: covidwho-1066256
ABSTRACT
PURPOSE:
The current evidence regarding iodine-containing compounds and iodine allergy cross-reactivity is reviewed.SUMMARY:
Iodine is an essential human nutrient found in the thyroid gland. It is used in the synthesis of the thyroid hormones thyroxine and triiodothyroxine. Patients who report having adverse reactions to iodine-containing substances are often labelled as having an "iodine allergy," which can result in delays in care or patients being denied essential iodinated contrast media (ICM) or other iodine-containing drugs. A literature review was conducted to evaluate the evidence regarding iodine allergy and iodine-containing drugs. Of 435 articles considered potentially appropriate for full review (plus 12 additional articles included on the basis of references from the eligible articles), 113 could not be obtained. After exclusion of 353 articles that did not meet all inclusion criteria, the remaining 81 articles were included in the review. The results of the literature review indicated that iodine has not been shown to be the allergen responsible for allergic reactions to iodinated contrast media, amiodarone, povidone-iodine, and other iodine-containing compounds.CONCLUSION:
There is a lack of evidence to support cross-reactivity between iodine-containing compounds in so called iodine-allergic individuals.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Drug Hypersensitivity
/
Amiodarone
/
Iodine
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Randomized controlled trials
/
Reviews
Limits:
Humans
Language:
English
Journal:
Am J Health Syst Pharm
Journal subject:
Pharmacy
/
Hospitals
Year:
2021
Document Type:
Article
Affiliation country:
Ajhp
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