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Relative Frequency and Risk Factors of COVID-19 Related Headache in a Sample of Egyptian Population: A Hospital-Based Study.
Hussein, Mona; Fathy, Wael; Eid, Ragaey A; Abdel-Hamid, Hoda M; Yehia, Ahmed; Sheemy, Mostafa S; Ragaie, Christine; Dahshan, Ahmed; Rizk, Hoda I; Laz, Nabila; Magdy, Rehab.
  • Hussein M; Department of Neurology, Beni-Suef University, Beni-Suef, Egypt.
  • Fathy W; Department of Anaesthesia, Surgical ICU and Pain management, Beni-Suef University, Beni-Suef, Egypt.
  • Eid RA; Department of Tropical medicine, Beni-suef University, Beni-Suef, Egypt.
  • Abdel-Hamid HM; Department of Chest diseases, Cairo University, Cairo, Egypt.
  • Yehia A; Department of Internal medicine, Beni-suef University, Beni-Suef, Egypt.
  • Sheemy MS; Department of Medical Microbiology and Immunology, Beni-suef University, Beni-Suef, Egypt.
  • Ragaie C; Department of Neurology, Cairo University, Cairo, Egypt.
  • Dahshan A; Department of Neurology, Cairo University, Cairo, Egypt.
  • Rizk HI; Department of Public Health and Community Medicine, Cairo University, Cairo, Egypt.
  • Laz N; Department of Chest diseases, Beni-Suef University, Beni-Suef, Egypt.
  • Magdy R; Department of Neurology, Cairo University, Cairo, Egypt.
Pain Med ; 22(9): 2092-2099, 2021 09 08.
Article in English | MEDLINE | ID: covidwho-1066388
ABSTRACT

OBJECTIVES:

Headache is considered one of the most frequent neurological manifestations of coronavirus disease 2019 (COVID-19). This work aimed to identify the relative frequency of COVID-19-related headache and to clarify the impact of clinical, laboratory findings of COVID-19 infection on headache occurrence and its response to analgesics.

DESIGN:

Cross-sectional study.

SETTING:

Recovered COVID-19 patients.

SUBJECTS:

In total, 782 patients with a confirmed diagnosis of COVID-19 infection.

METHODS:

Clinical, laboratory, and imaging data were obtained from the hospital medical records. Regarding patients who developed COVID-19 related headache, a trained neurologist performed an analysis of headache and its response to analgesics.

RESULTS:

The relative frequency of COVID-19 related headache among our sample was 55.1% with 95% confidence interval (CI) (.516-.586) for the estimated population prevalence. Female gender, malignancy, primary headache, fever, dehydration, lower levels of hemoglobin and platelets and higher levels of neutrophil/lymphocyte ratio (NLR) and CRP were significantly associated with COVID-19 related headache. Multivariate analysis revealed that female gender, fever, dehydration, primary headache, high NLR, and decreased platelet count were independent predictors of headache occurrence. By evaluating headache response to analgesics, old age, diabetes, hypertension, primary headache, severe COVID-19, steroid intake, higher CRP and ferritin and lower hemoglobin levels were associated with poor response to analgesics. Multivariate analysis revealed that primary headache, steroids intake, moderate and severe COVID-19 were independent predictors of non-response to analgesics.

DISCUSSION:

Headache occurs in 55.1% of patients with COVID-19. Female gender, fever, dehydration, primary headache, high NLR, and decreased platelet count are considered independent predictors of COVID-19 related headache.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans Country/Region as subject: Africa Language: English Journal: Pain Med Journal subject: Neurology / Psychophysiology Year: 2021 Document Type: Article Affiliation country: Pm

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans Country/Region as subject: Africa Language: English Journal: Pain Med Journal subject: Neurology / Psychophysiology Year: 2021 Document Type: Article Affiliation country: Pm