Viral strategies for circumventing p53: the case of severe acute respiratory syndrome coronavirus.
Curr Opin Oncol
; 33(2): 149-158, 2021 03 01.
Article
in English
| MEDLINE | ID: covidwho-1066437
ABSTRACT
PURPOSE OF REVIEW Virtually all viruses have evolved molecular instruments to circumvent cell mechanisms that may hamper their replication, dissemination, or persistence. Among these is p53, a key gatekeeper for cell division and survival that also regulates innate immune responses. This review summarizes the strategies used by different viruses and discusses the mechanisms deployed by SARS-CoV to target p53 activities. RECENT FINDINGS:
We propose a typology for the strategies used by different viruses to address p53 functions hit and run (e.g. IAV, ZIKV), hide and seek (e.g. HIV1), kidnap and exploit (e.g. EBV, HSV1), dominate and suppress (e.g. HR HPV). We discuss the mechanisms by which SARS nsp3 protein targets p53 for degradation and we speculate on the significance for Covid-19 pathogenesis and risk of cancer.SUMMARY:
p53 may operate as an intracellular antiviral defense mechanism. To circumvent it, SARS viruses adopt a kidnap and exploit strategy also shared by several viruses with transforming potential. This raises the question of whether SARS infections may make cells permissive to oncogenic DNA damage.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Tumor Suppressor Protein p53
/
SARS-CoV-2
/
COVID-19
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Curr Opin Oncol
Journal subject:
Neoplasms
Year:
2021
Document Type:
Article
Affiliation country:
CCO.0000000000000713
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