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Covert Subclinical Neurocognitive Sequelae During the Rehabilitation Course of Severe Coronavirus Disease 2019.
Tay, Matthew Rong Jie; Low, Yee Hong; Lim, Choie Cheio Tchoyoson; Umapathi, Thirugnanam; Thio, Jocelyn Mei Lin; Lui, Wen Li; Chan, Wai Lim William; Chua, Karen Sui Geok.
  • Tay MRJ; From the Department of Rehabilitation Medicine, Tan Tock Seng Hospital, Singapore (MRJT, YHL, JMLT, WLL, WLWC, KSGC); Department of Neuroradiology, National Neuroscience Institute, Singapore (CCTL); and Department of Neurology, National Neuroscience Institute, Singapore (TU).
Am J Phys Med Rehabil ; 100(1): 39-43, 2021 01 01.
Article in English | MEDLINE | ID: covidwho-1066488
Semantic information from SemMedBD (by NLM)
1. Signs and Symptom ASSOCIATED_WITH C5203670
Subject
Signs and Symptom
Predicate
ASSOCIATED_WITH
Object
C5203670
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Evaluation USES Psychometrics
Subject
Evaluation
Predicate
USES
Object
Psychometrics
4. Signs and Symptoms, Respiratory ASSOCIATED_WITH COVID-19
Subject
Signs and Symptoms, Respiratory
Predicate
ASSOCIATED_WITH
Object
COVID-19
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Evaluation USES Psychometrics
Subject
Evaluation
Predicate
USES
Object
Psychometrics
ABSTRACT
ABSTRACT Apart from respiratory symptoms, encephalopathy and a range of central nervous system complications have been described in coronavirus disease 2019. However, there is a lack of published literature on the rehabilitative course and functional outcomes of severe coronavirus disease 2019 with encephalopathy. In addition, the presence of subclinical neurocognitive sequelae during postacute rehabilitation has not been described and may be underrecognized by rehabilitation providers. We report the rehabilitative course of a middle-aged male patient with severe coronavirus disease 2019 who required intensive care and mechanical ventilation. During postacute inpatient rehabilitation for severe intensive care unit-related weakness, an abnormal cognitive screen prompted brain magnetic resonance imaging, which revealed destructive leukoencephalopathy. Subsequently, detailed psychometric evaluation revealed significant impairments in the domains of processing speed and executive function. After 40 days of intensive inpatient rehabilitation, he was discharged home with independent function. This report highlights the need for an increased awareness of covert subclinical neurocognitive sequelae, the role of comprehensive rehabilitation, and value of routine cognitive screening therein and describes the neurocognitive features in severe COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Critical Care / Leukoencephalopathies / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Language: English Journal: Am J Phys Med Rehabil Journal subject: Physical Medicine / Rehabilitation Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Critical Care / Leukoencephalopathies / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Language: English Journal: Am J Phys Med Rehabil Journal subject: Physical Medicine / Rehabilitation Year: 2021 Document Type: Article