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Review of COVID-19 and male genital tract.
Sheikhzadeh Hesari, Farzam; Hosseinzadeh, Seyedeh Shaghayegh; Asl Monadi Sardroud, Mohammad Ali.
  • Sheikhzadeh Hesari F; Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
  • Hosseinzadeh SS; Tabriz University of Medical Sciences, Tabriz, Iran.
  • Asl Monadi Sardroud MA; Tabriz Branch, Department of Urology, Islamic Azad University, Tabriz, Iran.
Andrologia ; 53(1): e13914, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1087946
ABSTRACT
COVID-19 pandemic leads to health challenges globally, and its diverse aspects need to be uncovered. Multi-organ injuries have been reported by describing potential SARS-CoV-2 entrance routes ACE2 and TMPRSS2. Since these cell surface receptors' expression has been disclosed within the male reproductive system, its susceptibility to being infected by SARS-CoV-2 has been summarised through this literature review. Expression of ACE2 and TMPRSS2 at RNA or protein level has been reported across various investigations indicates that the male genitalia potentially is vulnerable to SARS-CoV-2 infection. Presence of SARS-CoV-2 within semen samples and following direct viral damage, secondary inflammatory response causing orchitis or testicular discomfort and finally the amount of viral load leading testicular damage and immune response activation are among probable underlying mechanisms. Therefore, genital examination and laboratory tests should be considered to address the male reproductive tract complications and fertility issues.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Genitalia, Male Type of study: Reviews Limits: Humans / Male Language: English Journal: Andrologia Year: 2021 Document Type: Article Affiliation country: And.13914

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Genitalia, Male Type of study: Reviews Limits: Humans / Male Language: English Journal: Andrologia Year: 2021 Document Type: Article Affiliation country: And.13914