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Coronaviruses Associated with the Superfamily Musteloidea.
Stout, Alison E; Guo, Qinghua; Millet, Jean K; de Matos, Ricardo; Whittaker, Gary R.
  • Stout AE; Department of Microbiology & Immunology, Cornell University, Ithaca, New York, USA.
  • Guo Q; Master of Public Health Program, Cornell University, Ithaca, New York, USA.
  • Millet JK; Université Paris-Saclay, INRAE, UVSQ, Virologie et Immunologie Moléculaires, Jouy-en-Josas, France.
  • de Matos R; Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
  • Whittaker GR; Department of Microbiology & Immunology, Cornell University, Ithaca, New York, USA grw7@cornell.edu.
mBio ; 12(1)2021 01 19.
Article in English | MEDLINE | ID: covidwho-1066820
ABSTRACT
Among the animal superfamily Musteloidea, which includes those commonly known as mustelids, naturally occurring and species-specific alphacoronavirus infections have been observed in both mink (Mustela vison/Neovison vison) and domestic ferrets (Mustela putorius furo). Ferret systemic coronavirus (FRSCV), in particular, has been associated with a rare but fatal systemic disease. In recent months, it has become apparent that both minks and ferrets are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a betacoronavirus and the cause of the coronavirus disease 2019 (COVID-19) pandemic. Several mink farms have experienced SARS-CoV-2 outbreaks, and experimental models have demonstrated susceptibility of ferrets to SARS-CoV-2. The potential for pet ferrets to become infected with SARS-CoV-2, however, remains elusive. During the 2002-2003 SARS epidemic, it was also apparent that ferrets were susceptible to SARS-CoV and could be utilized in vaccine development. From a comparative standpoint, understanding the relationships between different infections and disease pathogenesis in the animal superfamily Musteloidea may help elucidate viral infection and transmission mechanisms, as well as treatment and prevention strategies for coronaviruses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Caniformia / Coronavirus Infections / Coronavirus Type of study: Randomized controlled trials Topics: Vaccines Limits: Animals Language: English Year: 2021 Document Type: Article Affiliation country: MBio.02873-20

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Caniformia / Coronavirus Infections / Coronavirus Type of study: Randomized controlled trials Topics: Vaccines Limits: Animals Language: English Year: 2021 Document Type: Article Affiliation country: MBio.02873-20