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Dynamics of the seroprevalence of SARS-CoV-2 antibodies among healthcare workers at a COVID-19 referral hospital in Milan, Italy.
Milazzo, Laura; Lai, Alessia; Pezzati, Laura; Oreni, Letizia; Bergna, Annalisa; Conti, Federico; Meroni, Cristina; Minisci, Davide; Galli, Massimo; Corbellino, Mario; Antinori, Spinello; Ridolfo, Anna Lisa.
  • Milazzo L; Department of Infectious Diseases, ASST Fatebenefratelli Sacco, Milano, Italy laura.milazzo@asst-fbf-sacco.it.
  • Lai A; Luigi Sacco Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milano, Lombardia, Italy.
  • Pezzati L; Luigi Sacco Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milano, Lombardia, Italy.
  • Oreni L; Department of Infectious Diseases, ASST Fatebenefratelli Sacco, Milano, Italy.
  • Bergna A; Luigi Sacco Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milano, Lombardia, Italy.
  • Conti F; Luigi Sacco Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milano, Lombardia, Italy.
  • Meroni C; Department of Infectious Diseases, ASST Fatebenefratelli Sacco, Milano, Italy.
  • Minisci D; Department of Infectious Diseases, ASST Fatebenefratelli Sacco, Milano, Italy.
  • Galli M; Luigi Sacco Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milano, Lombardia, Italy.
  • Corbellino M; Department of Infectious Diseases, ASST Fatebenefratelli Sacco, Milano, Italy.
  • Antinori S; Luigi Sacco Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milano, Lombardia, Italy.
  • Ridolfo AL; Department of Infectious Diseases, ASST Fatebenefratelli Sacco, Milano, Italy.
Occup Environ Med ; 2021 Feb 04.
Article in English | MEDLINE | ID: covidwho-1066929
ABSTRACT

OBJECTIVES:

Healthcare workers (HCWs) are at high risk of developing SARS-CoV-2 infection. The aim of this single-centre prospective study was to evaluate the trend of SARS-CoV-2 seroprevalence in HCWs working at the primary referral centre for infectious diseases and bioemergencies (eg, COVID-19) in Northern Italy and investigate the factors associated with seroconversion.

METHODS:

Six hundred and seventy-nine HCW volunteers were tested for anti-SARS-CoV-2 antibodies three times between 4 March and 27 May 2020 and completed a questionnaire covering COVID-19 exposure, symptoms and personal protective equipment (PPE) training and confidence at each time.

RESULTS:

SARS-CoV-2 seroprevalence rose from 3/679 to 26/608 (adjusted prevalence 0.5%, 95% CI 0.1 to 1.7% and 5.4%, 95% CI 3.6 to 7.9, respectively) between the first two time points and then stabilised, in line with the curve of the COVID-19 epidemic in Milan. From the first time point, 61.6% of the HCWs had received training in the use of PPE and 17 (61.5%) of those who proved to be seropositive reported symptoms compatible with SARS-CoV-2 infection. Contacts with ill relatives or friends and self-reported symptoms were independently associated with an increased likelihood of seroconversion (p<0.0001 for both), whereas there was no significant association with professional exposure.

CONCLUSION:

The seroprevalence of SARS-CoV-2 among the HCWs at our COVID-19 referral hospital was low at the time of the peak of the epidemic. The seroconversions were mainly attributable to extrahospital contacts, probably because the hospital readily adopted effective infection control measures. The relatively high number of asymptomatic seropositive HCWs highlights the need to promptly identify and isolate potentially infectious HCWs.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal subject: Occupational Medicine / Environmental Health Year: 2021 Document Type: Article Affiliation country: Oemed-2020-107060

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal subject: Occupational Medicine / Environmental Health Year: 2021 Document Type: Article Affiliation country: Oemed-2020-107060