Toward Respiratory Support of Critically Ill COVID-19 Patients Using Repurposed Kidney Hollow Fiber Membrane Dialysers to Oxygenate the Blood.
J Healthc Eng
; 2020: 8862645, 2020.
Article
in English
| MEDLINE | ID: covidwho-1066956
ABSTRACT
The COVID-19 pandemic has highlighted resource constraints in respiratory support. The oxygen transfer characteristics of a specific hollow fiber membrane dialyser was investigated with a view to repurposing the device as a low-cost, readily available blood oxygenator. Oxygen transfer in a low-flux hollow fiber dialyser with a polysulfone membrane was studied by passing first water and then blood through the dialyser in countercurrent to high-purity oxygen. Oxygen transfer rates of about 15% of the nominal 250 ml (STP)/min of a typical adult oxygen consumption rate were achieved for blood flow rates of 500 ml/min. Using two such dialysis devices in parallel could provide up to 30% of the nominal oxygen consumption. Specific hollow fiber dialysis devices operating with suitable pumps in a veno-venous access configuration could provide a cost-effective and readily available supplementation of respiratory support in the face of severe resource constraints.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Oxygenators
/
Renal Dialysis
/
COVID-19
Limits:
Humans
Language:
English
Journal:
J Healthc Eng
Year:
2020
Document Type:
Article
Affiliation country:
2020
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