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Acute Ischemic Stroke and COVID-19: An Analysis of 27 676 Patients.
Qureshi, Adnan I; Baskett, William I; Huang, Wei; Shyu, Daniel; Myers, Danny; Raju, Murugesan; Lobanova, Iryna; Suri, M Fareed K; Naqvi, S Hasan; French, Brandi R; Siddiq, Farhan; Gomez, Camilo R; Shyu, Chi-Ren.
  • Qureshi AI; Zeenat Qureshi Institute, St Cloud, MN (A.I.Q, W.H., I.L.).
  • Baskett WI; Department of Neurology (A.I.Q., W.H., I.L., B.R.F., C.R.G.), University of Missouri, Columbia.
  • Huang W; Institute for Data Science and Informatics (W.I.B., M.R., C.-R.S.), University of Missouri, Columbia.
  • Shyu D; Zeenat Qureshi Institute, St Cloud, MN (A.I.Q, W.H., I.L.).
  • Myers D; Department of Neurology (A.I.Q., W.H., I.L., B.R.F., C.R.G.), University of Missouri, Columbia.
  • Raju M; Department of Medicine (D.S.), University of Missouri, Columbia.
  • Lobanova I; Tiger Institute for Health Innovation, Cerner Corporation, Columbia, MO (D.M.).
  • Suri MFK; Institute for Data Science and Informatics (W.I.B., M.R., C.-R.S.), University of Missouri, Columbia.
  • Naqvi SH; Department of Neurology (A.I.Q., W.H., I.L., B.R.F., C.R.G.), University of Missouri, Columbia.
  • French BR; St. Cloud Hospital, MN (M.F.K.S.).
  • Siddiq F; Department of Internal Medicine (S.H.N.), University of Missouri, Columbia.
  • Gomez CR; Department of Neurology (A.I.Q., W.H., I.L., B.R.F., C.R.G.), University of Missouri, Columbia.
  • Shyu CR; Division of Neurosurgery (F.S.), University of Missouri, Columbia.
Stroke ; 52(3): 905-912, 2021 03.
Article in English | MEDLINE | ID: covidwho-1066984
ABSTRACT
BACKGROUND AND

PURPOSE:

Acute ischemic stroke may occur in patients with coronavirus disease 2019 (COVID-19), but risk factors, in-hospital events, and outcomes are not well studied in large cohorts. We identified risk factors, comorbidities, and outcomes in patients with COVID-19 with or without acute ischemic stroke and compared with patients without COVID-19 and acute ischemic stroke.

METHODS:

We analyzed the data from 54 health care facilities using the Cerner deidentified COVID-19 dataset. The dataset included patients with an emergency department or inpatient encounter with discharge diagnoses codes that could be associated to suspicion of or exposure to COVID-19 or confirmed COVID-19.

RESULTS:

A total of 103 (1.3%) patients developed acute ischemic stroke among 8163 patients with COVID-19. Among all patients with COVID-19, the proportion of patients with hypertension, diabetes, hyperlipidemia, atrial fibrillation, and congestive heart failure was significantly higher among those with acute ischemic stroke. Acute ischemic stroke was associated with discharge to destination other than home or death (relative risk, 2.1 [95% CI, 1.6-2.4]; P<0.0001) after adjusting for potential confounders. A total of 199 (1.0%) patients developed acute ischemic stroke among 19 513 patients without COVID-19. Among all ischemic stroke patients, COVID-19 was associated with discharge to destination other than home or death (relative risk, 1.2 [95% CI, 1.0-1.3]; P=0.03) after adjusting for potential confounders.

CONCLUSIONS:

Acute ischemic stroke was infrequent in patients with COVID-19 and usually occurs in the presence of other cardiovascular risk factors. The risk of discharge to destination other than home or death increased 2-fold with occurrence of acute ischemic stroke in patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Atrial Fibrillation / Hospital Mortality / Diabetes Mellitus / Ischemic Stroke / COVID-19 / Heart Failure / Hyperlipidemias / Hypertension Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Stroke Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Atrial Fibrillation / Hospital Mortality / Diabetes Mellitus / Ischemic Stroke / COVID-19 / Heart Failure / Hyperlipidemias / Hypertension Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Stroke Year: 2021 Document Type: Article