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Effect of asthma and asthma medication on the prognosis of patients with COVID-19.
Choi, Yong Jun; Park, Ju-Young; Lee, Hye Sun; Suh, Jin; Song, Jeung Yoon; Byun, Min Kwang; Cho, Jae Hwa; Kim, Hyung Jung; Lee, Jae-Hyun; Park, Jung-Won; Park, Hye Jung.
  • Choi YJ; Dept of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Park JY; Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Lee HS; Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea craft7820@yuhs.ac.
  • Suh J; Dept of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Song JY; Dept of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Byun MK; Dept of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Cho JH; Dept of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Kim HJ; Dept of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Lee JH; Division of Allergy and Immunology, Dept of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Park JW; Institute of Allergy, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Park HJ; Division of Allergy and Immunology, Dept of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Eur Respir J ; 57(3)2021 03.
Article in English | MEDLINE | ID: covidwho-1067168
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) has spread worldwide rapidly. However, the effects of asthma, asthma medication and asthma severity on the clinical outcomes of COVID-19 have not yet been established.

METHODS:

The study included 7590 de-identified patients, who were confirmed to have COVID-19 using the severe acute respiratory syndrome coronavirus 2 RNA-PCR tests conducted up to May 15, 2020; we used the linked-medical claims data provided by the Health Insurance Review and Assessment Service. Asthma and asthma severity (steps suggested by the Global Initiative for Asthma) were defined using the diagnostic code and history of asthma medication usage.

RESULTS:

Among 7590 COVID-19 patients, 218 (2.9%) had underlying asthma. The total medical cost associated with COVID-19 patients with underlying asthma was significantly higher than that of other patients. Mortality rate for COVID-19 patients with underlying asthma (7.8%) was significantly higher than that of other patients (2.8%; p<0.001). However, asthma was not an independent risk factor for the clinical outcomes of COVID-19 after adjustment, nor did asthma medication use and asthma severity affect the clinical outcomes of COVID-19. However, use of oral short-acting ß2-agonists was an independent factor to increase the total medical cost burden. Patients with step 5 asthma showed significant prolonged duration of admission compared to those with step 1 asthma in both univariate and multivariate analysis.

CONCLUSIONS:

Asthma led to poor outcomes of COVID-19; however, underlying asthma, use of asthma medication and asthma severity were not independent factors for poor clinical outcomes of COVID-19, generally.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Anti-Asthmatic Agents / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Anti-Asthmatic Agents / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Language: English Year: 2021 Document Type: Article