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Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes.
Yang, Jing; Chen, Tan; Zhou, Yafeng.
  • Yang J; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
  • Chen T; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. chentan12345@126.com.
  • Zhou Y; Department of Cardiology, Dushuhu Public Hospital Affiliated to Soochow University, Suzhou, 215000, China. chentan12345@126.com.
Hereditas ; 158(1): 4, 2021 Jan 04.
Article in English | MEDLINE | ID: covidwho-1067345
ABSTRACT

BACKGROUND:

The coronavirus disease 2019 (COVID-19) has spread rapidly around the world. In addition to common respiratory symptoms such as cough and fever, some patients also have cardiac injury, however, the mechanism of cardiac injury is not clear. In this study, we analyzed the RNA expression atlases of angiotensin-converting enzyme 2(ACE2), cathepsin B (CTSB) and cathepsin L (CTSL) in the human embryonic heart at single-cell resolution.

RESULTS:

The results showed that ACE2 was preferentially enriched in cardiomyocytes. Interestingly, serine protease transmembrane serine protease 2 (TMPRSS2) had less expression in cardiomyocytes, but CTSB and CTSL, which belonged to cell protease, could be found to be enriched in cardiomyocytes. The results of enrichment analysis showed that differentially expressed genes (DEGs) in ACE2-positive cardiomyocytes were mainly enriched in the processes of cardiac muscle contraction, regulation of cardiac conduction, mitochondrial respiratory chain, ion channel binding, adrenergic signaling in cardiomyocytes and viral transcription.

CONCLUSIONS:

Our study suggests that both atrial and ventricular cardiomyocytes are potentially susceptible to severe acute respiratory syndrome coronavirus-2(SARS-CoV-2), and SARS-CoV-2 may enter ventricular cardiomyocytes using CTSB/CTSL for S protein priming. This may be the partial cellular mechanism of cardiac injury in patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gene Expression Regulation, Developmental / Myocytes, Cardiac / Single-Cell Analysis / SARS-CoV-2 / COVID-19 / Heart Type of study: Observational study Limits: Humans Language: English Journal: Hereditas Year: 2021 Document Type: Article Affiliation country: S41065-020-00168-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gene Expression Regulation, Developmental / Myocytes, Cardiac / Single-Cell Analysis / SARS-CoV-2 / COVID-19 / Heart Type of study: Observational study Limits: Humans Language: English Journal: Hereditas Year: 2021 Document Type: Article Affiliation country: S41065-020-00168-4