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COVID-19 and nutritional deficiency: a review of existing knowledge.
Muthuvattur Pallath, Meghana; Ahirwar, Ashok Kumar; Chandra Tripathi, Satyendra; Asia, Priyanka; Sakarde, Apurva; Gopal, Niranjan.
  • Muthuvattur Pallath M; All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
  • Ahirwar AK; Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
  • Chandra Tripathi S; Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
  • Asia P; Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
  • Sakarde A; Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
  • Gopal N; Department of Biochemistry, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.
Horm Mol Biol Clin Investig ; 42(1): 77-85, 2021 Feb 04.
Article in English | MEDLINE | ID: covidwho-1067449
Semantic information from SemMedBD (by NLM)
1. Infected PROCESS_OF Persons
Subject
Infected
Predicate
PROCESS_OF
Object
Persons
2. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
3. Chronic disease PROCESS_OF Old age
Subject
Chronic disease
Predicate
PROCESS_OF
Object
Old age
4. Cardiovascular Diseases PROCESS_OF geriatric patients
Subject
Cardiovascular Diseases
Predicate
PROCESS_OF
Object
geriatric patients
5. Comorbidity PROCESS_OF geriatric patients
Subject
Comorbidity
Predicate
PROCESS_OF
Object
geriatric patients
6. Diabetes Mellitus PROCESS_OF geriatric patients
Subject
Diabetes Mellitus
Predicate
PROCESS_OF
Object
geriatric patients
7. Malnutrition PROCESS_OF geriatric patients
Subject
Malnutrition
Predicate
PROCESS_OF
Object
geriatric patients
8. Micronutrients CAUSES Impaired immune responses
Subject
Micronutrients
Predicate
CAUSES
Object
Impaired immune responses
9. cytokine AFFECTS Antibody Formation
Subject
cytokine
Predicate
AFFECTS
Object
Antibody Formation
10. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
11. Infected PROCESS_OF Persons
Subject
Infected
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PROCESS_OF
Object
Persons
12. COVID-19 PROCESS_OF Persons
Subject
COVID-19
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PROCESS_OF
Object
Persons
13. Chronic disease PROCESS_OF Old age
Subject
Chronic disease
Predicate
PROCESS_OF
Object
Old age
14. Cardiovascular Diseases PROCESS_OF geriatric patients
Subject
Cardiovascular Diseases
Predicate
PROCESS_OF
Object
geriatric patients
15. Comorbidity PROCESS_OF geriatric patients
Subject
Comorbidity
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PROCESS_OF
Object
geriatric patients
16. Diabetes Mellitus PROCESS_OF geriatric patients
Subject
Diabetes Mellitus
Predicate
PROCESS_OF
Object
geriatric patients
17. Malnutrition PROCESS_OF geriatric patients
Subject
Malnutrition
Predicate
PROCESS_OF
Object
geriatric patients
18. Micronutrients CAUSES Impaired immune responses
Subject
Micronutrients
Predicate
CAUSES
Object
Impaired immune responses
19. cytokine AFFECTS Antibody Formation
Subject
cytokine
Predicate
AFFECTS
Object
Antibody Formation
20. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
COVID-19 has resulted in an ongoing global pandemic, which spread largely among people who have had close contact with the infected person. The immunopathology of the SARS-CoV-2 virus includes the production of an excess amount of pro-inflammatory cytokines "a cytokine-storm". The respiratory system (main), cardiovascular system and the gastrointestinal tract are the most affected body systems during viral infection. It has been found that most of the patients who require admission to hospital are elderly or have chronic underlying diseases. Higher cases of malnutrition and co-morbidities like diabetes mellitus and cardiovascular diseases are reported in elderly patients due to which, the immune system weakens and hence, the response to the virus is diminished in magnitude. A deficiency of micronutrients results in impaired immune responses leading to improper secretion of cytokines, alterations in secretory antibody response and antibody affinity which increases susceptibility to viral infection. The deficiency of various micronutrients in COVID-19 patient can be treated by appropriate nutritional supplements, prescribed after evaluating the patients' nutritional status. Here we aim to highlight the role of a few particular nutrients namely Vitamin D, Vitamin C, Omega-3 fatty acids, Zinc and Magnesium along with the synergistic roles they play in enhancing immunity and thus, maintaining homeostasis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Malnutrition / COVID-19 Type of study: Experimental Studies / Observational study Topics: Long Covid / Traditional medicine Limits: Humans Language: English Journal: Horm Mol Biol Clin Investig Year: 2021 Document Type: Article Affiliation country: Hmbci-2020-0074

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Malnutrition / COVID-19 Type of study: Experimental Studies / Observational study Topics: Long Covid / Traditional medicine Limits: Humans Language: English Journal: Horm Mol Biol Clin Investig Year: 2021 Document Type: Article Affiliation country: Hmbci-2020-0074