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COVID-19 associated central nervous system manifestations, mental and neurological symptoms: a systematic review and meta-analysis.
Soltani, Saber; Tabibzadeh, Alireza; Zakeri, Armin; Zakeri, Amir Mohammad; Latifi, Tayebeh; Shabani, Mahdi; Pouremamali, Amir; Erfani, Yousef; Pakzad, Iraj; Malekifar, Pooneh; Valizadeh, Reza; Zandi, Milad; Pakzad, Reza.
  • Soltani S; Department of Virology, School of Public Health, Tehran University of Medical Sciences, 1417613151, Tehran, Iran.
  • Tabibzadeh A; Research Center for Clinical Virology, Tehran University of Medical Sciences, 1417613151, Tehran, Iran.
  • Zakeri A; Department of Virology, Iran University of Medical Sciences, 1449614535, Tehran, Iran.
  • Zakeri AM; Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, 111-14115, Tehran, Iran.
  • Latifi T; Pediatric Surgery Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, 22439962,Tehran, Iran.
  • Shabani M; Department of Virology, School of Public Health, Tehran University of Medical Sciences, 1417613151, Tehran, Iran.
  • Pouremamali A; Department of Virology, School of Public Health, Tehran University of Medical Sciences, 1417613151, Tehran, Iran.
  • Erfani Y; Department of Medical Virology, Faculty of Medical Sciences, Tarbiat Modares University, 111-14115, Tehran, Iran.
  • Pakzad I; Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University Medical Sciences, 1417613151, Tehran, Iran.
  • Malekifar P; Department of Microbiology, School of Allied Medical Sciences, Ilam University Medical Sciences, 6939177143, Ilam, Iran.
  • Valizadeh R; Department of Epidemiology, School of Public Health, Tehran University Medical Sciences, 1417613151, Tehran, Iran.
  • Zandi M; Department of Psychiatry, Psychosocial Injures Research Center, Ilam University Medical Sciences, 6939177143, Ilam, Iran.
  • Pakzad R; Department of Virology, School of Public Health, Tehran University of Medical Sciences, 1417613151, Tehran, Iran.
Rev Neurosci ; 32(3): 351-361, 2021 04 27.
Article in English | MEDLINE | ID: covidwho-1067453
Semantic information from SemMedBD (by NLM)
1. Psychiatric symptom ASSOCIATED_WITH COVID-19
Subject
Psychiatric symptom
Predicate
ASSOCIATED_WITH
Object
COVID-19
2. Neurologic Symptoms PROCESS_OF Relative (related person)
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Relative (related person)
3. Psychiatric symptom ASSOCIATED_WITH COVID-19
Subject
Psychiatric symptom
Predicate
ASSOCIATED_WITH
Object
COVID-19
4. Neurologic Symptoms PROCESS_OF Relative (related person)
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Relative (related person)
ABSTRACT
The ongoing pandemic of Coronavirus disease 2019 (COVID-19) has infected more than 27 million confirmed cases and 8,90,000 deaths all around the world. Verity of viral infections can infect the nervous system; these viral infections can present a wide range of manifestation. The aim of the current study was to systematically review the COVID-19 associated central nervous system manifestations, mental and neurological symptoms. For that we conducted a comprehensive systematic literature review of four online databases, including Web of Science, PubMed, Scopus and Embase. All relevant articles that reported psychiatric/psychological symptoms or disorders in COVID-19 without considering time and language restrictions were assessed. All the study procedures were performed based on the PRISMA criteria. Due to the screening, 14 studies were included. The current study result indicated that, the pooled prevalence of CNS or mental associated disorders with 95% CI was 50.68% (6.68-93.88). The most prevalence symptoms were hyposmia/anosmia/olfactory dysfunction (number of study 10) with 36.20% (14.99-60.51). Only one study reported numbness/paresthesia and dysphonia. Pooled prevalence of numbness/paresthesia and dysphonia was 5.83% (2.17-12.25) and 2.39% (10.75-14.22). The pooled prevalence of depression and anxiety was 3.52% (2.62-4.54) and 13.92% (9.44-19.08). Our findings demonstrate that COVID-19 has a certain relation with neurological symptoms. The hypsomia, anosmia or olfactory dysfunction was most frequent symptom. Other symptoms were headache or dizziness, dysgeusia or ageusia, dysphonia and fatigue. Depression, anxiety, and confusion were less frequent symptoms.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Anxiety / Depression / Anosmia / COVID-19 Type of study: Observational study / Qualitative research / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Rev Neurosci Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: Revneuro-2020-0108

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Anxiety / Depression / Anosmia / COVID-19 Type of study: Observational study / Qualitative research / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Rev Neurosci Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: Revneuro-2020-0108