Natural Substances and Semisynthetic Derivatives as Potential Alternative Products Against SARS-CoV-2.
Mini Rev Med Chem
; 21(13): 1596-1611, 2021.
Article
in English
| MEDLINE | ID: covidwho-1067526
ABSTRACT
BACKGROUND AND OBJECTIVE:
Today, a new ß-coronavirus called SARS-CoV-2 has emerged and it is causing a global pandemic. Inter-human transmission studies have indicated a significant role of aerosols in the transmission of many respiratory viruses. Hence, it is very important to decrease the spread of the virus through disinfectant agents. This review aimed to provide an overview related to possible alternative inhibitory molecules against this virus.METHOD:
The literature search was performed in the MEDLINE electronic database using the public access known as NCBI-PUBMED. Keywords "coronavirus" and "SARS-CoV-2" and "COVID19" were used. No specific time range was used.RESULTS:
We provide a review related to structure, anti-coronavirus activity and molecular mechanism of natural substances and semisynthetic derivatives such as glycopeptides, lipopeptides, probiotics, surfactants, terpenes and resveratrol. We also include the latest in vitro experiments with anti-SARSCoV- 2 activity. We also provide the theoretical basis for discussing the prospects of such natural molecules as possible alternative anti-Coronavirus products, so as to develop a complete screening for future applications.CONCLUSION:
In summary, this review suggest to investigate deeper several molecules most of which belong to natural substances to fight COVID19 disease.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Biological Products
/
Drug Design
/
SARS-CoV-2
/
COVID-19 Drug Treatment
Type of study:
Reviews
Limits:
Humans
Language:
English
Journal:
Mini Rev Med Chem
Journal subject:
Chemistry
Year:
2021
Document Type:
Article
Affiliation country:
1389557521666210203154541
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