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Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020.
Jeffery-Smith, Anna; Iyanger, Nalini; Williams, Sarah V; Chow, J Yimmy; Aiano, Felicity; Hoschler, Katja; Lackenby, Angie; Ellis, Joanna; Platt, Steven; Miah, Shahjahan; Brown, Kevin; Amirthalingam, Gayatri; Patel, Monika; Ramsay, Mary E; Gopal, Robin; Charlett, Andre; Ladhani, Shamez N; Zambon, Maria.
  • Jeffery-Smith A; National Infection Service Public Health England, London, United Kingdom.
  • Iyanger N; London Coronavirus Response Centre, Public Health England, London, United Kingdom.
  • Williams SV; London Coronavirus Response Centre, Public Health England, London, United Kingdom.
  • Chow JY; London Coronavirus Response Centre, Public Health England, London, United Kingdom.
  • Aiano F; National Infection Service Public Health England, London, United Kingdom.
  • Hoschler K; National Infection Service Public Health England, London, United Kingdom.
  • Lackenby A; National Infection Service Public Health England, London, United Kingdom.
  • Ellis J; National Infection Service Public Health England, London, United Kingdom.
  • Platt S; National Infection Service Public Health England, London, United Kingdom.
  • Miah S; National Infection Service Public Health England, London, United Kingdom.
  • Brown K; National Infection Service Public Health England, London, United Kingdom.
  • Amirthalingam G; National Infection Service Public Health England, London, United Kingdom.
  • Patel M; National Infection Service Public Health England, London, United Kingdom.
  • Ramsay ME; National Infection Service Public Health England, London, United Kingdom.
  • Gopal R; National Infection Service Public Health England, London, United Kingdom.
  • Charlett A; Data and Analytical Sciences, Public Health England, London, United Kingdom.
  • Ladhani SN; National Infection Service Public Health England, London, United Kingdom.
  • Zambon M; National Infection Service Public Health England, London, United Kingdom.
Euro Surveill ; 26(5)2021 02.
Article in English | MEDLINE | ID: covidwho-1067625
ABSTRACT
Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive 87; RT-PCR-positive 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI) 72.7-99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI 78.8-99.3%) using a penalised logistic regression model.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Outbreaks / Reinfection / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Nursing Homes Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: 1560-7917.ES.2021.26.5.2100092

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Outbreaks / Reinfection / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Nursing Homes Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: 1560-7917.ES.2021.26.5.2100092