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Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020.
Jeffery-Smith, Anna; Iyanger, Nalini; Williams, Sarah V; Chow, J Yimmy; Aiano, Felicity; Hoschler, Katja; Lackenby, Angie; Ellis, Joanna; Platt, Steven; Miah, Shahjahan; Brown, Kevin; Amirthalingam, Gayatri; Patel, Monika; Ramsay, Mary E; Gopal, Robin; Charlett, Andre; Ladhani, Shamez N; Zambon, Maria.
  • Jeffery-Smith A; National Infection Service Public Health England, London, United Kingdom.
  • Iyanger N; London Coronavirus Response Centre, Public Health England, London, United Kingdom.
  • Williams SV; London Coronavirus Response Centre, Public Health England, London, United Kingdom.
  • Chow JY; London Coronavirus Response Centre, Public Health England, London, United Kingdom.
  • Aiano F; National Infection Service Public Health England, London, United Kingdom.
  • Hoschler K; National Infection Service Public Health England, London, United Kingdom.
  • Lackenby A; National Infection Service Public Health England, London, United Kingdom.
  • Ellis J; National Infection Service Public Health England, London, United Kingdom.
  • Platt S; National Infection Service Public Health England, London, United Kingdom.
  • Miah S; National Infection Service Public Health England, London, United Kingdom.
  • Brown K; National Infection Service Public Health England, London, United Kingdom.
  • Amirthalingam G; National Infection Service Public Health England, London, United Kingdom.
  • Patel M; National Infection Service Public Health England, London, United Kingdom.
  • Ramsay ME; National Infection Service Public Health England, London, United Kingdom.
  • Gopal R; National Infection Service Public Health England, London, United Kingdom.
  • Charlett A; Data and Analytical Sciences, Public Health England, London, United Kingdom.
  • Ladhani SN; National Infection Service Public Health England, London, United Kingdom.
  • Zambon M; National Infection Service Public Health England, London, United Kingdom.
Euro Surveill ; 26(5)2021 02.
Article in English | MEDLINE | ID: covidwho-1067625
Semantic information from SemMedBD (by NLM)
1. Antibodies PREVENTS Reinfection
Subject
Antibodies
Predicate
PREVENTS
Object
Reinfection
2. Antibodies PREVENTS Reinfection
Subject
Antibodies
Predicate
PREVENTS
Object
Reinfection
ABSTRACT
Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive 87; RT-PCR-positive 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI) 72.7-99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI 78.8-99.3%) using a penalised logistic regression model.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Outbreaks / Reinfection / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Nursing Homes Type of study: Observational study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: 1560-7917.ES.2021.26.5.2100092

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Outbreaks / Reinfection / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Nursing Homes Type of study: Observational study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: 1560-7917.ES.2021.26.5.2100092