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The SARS-CoV-2-Inactivating Activity of Hydroxytyrosol-Rich Aqueous Olive Pulp Extract (HIDROX®) and Its Use as a Virucidal Cream for Topical Application.
Takeda, Yohei; Jamsransuren, Dulamjav; Matsuda, Sachiko; Crea, Roberto; Ogawa, Haruko.
  • Takeda Y; Research Center for Global Agromedicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido 080-8555, Japan.
  • Jamsransuren D; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido 080-8555, Japan.
  • Matsuda S; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido 080-8555, Japan.
  • Crea R; Oliphenol LLC., 26225 Eden Landing Road, Suite C, Hayward, CA 94545, USA.
  • Ogawa H; Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido 080-8555, Japan.
Viruses ; 13(2)2021 02 02.
Article in English | MEDLINE | ID: covidwho-1154509
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally. Although measures to control SARS-CoV-2, namely, vaccination, medication, and chemical disinfectants are being investigated, there is an increase in the demand for auxiliary antiviral approaches using natural compounds. Here we have focused on hydroxytyrosol (HT)-rich aqueous olive pulp extract (HIDROX®) and evaluated its SARS-CoV-2-inactivating activity in vitro. We showed that the HIDROX solution exhibits time- and concentration-dependent SARS-CoV-2-inactivating activities, and that HIDROX has more potent virucidal activity than pure HT. The evaluation of the mechanism of action suggested that both HIDROX and HT induced structural changes in SARS-CoV-2, which changed the molecular weight of the spike proteins. Even though the spike protein is highly glycosylated, this change was induced regardless of the glycosylation status. In addition, HIDROX or HT treatment disrupted the viral genome. Moreover, the HIDROX-containing cream applied on film showed time- and concentration-dependent SARS-CoV-2-inactivating activities. Thus, the HIDROX-containing cream can be applied topically as an antiviral hand cream. Our findings suggest that HIDROX contributes to improving SARS-CoV-2 control measures.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Phenylethyl Alcohol / Plant Extracts / Olea / SARS-CoV-2 Type of study: Experimental Studies Topics: Vaccines Limits: Animals Language: English Year: 2021 Document Type: Article Affiliation country: V13020232

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Phenylethyl Alcohol / Plant Extracts / Olea / SARS-CoV-2 Type of study: Experimental Studies Topics: Vaccines Limits: Animals Language: English Year: 2021 Document Type: Article Affiliation country: V13020232